Comparative Analysis of Salivary Cortisol in Young Adult Patients with Temporomandibular Disorders

다국어 초록 (Multilingual Abstract)

Purpose: The goal of this study was to investigate the causative factors related to the stress of temporomandibular disorders (TMDs) by evaluating salivary cortisol concentration in young adult TMD patients and control groups.
Methods: Saliva was obtained from 32 young adult TMDs patients and 34 control patients without a history of TMDs who visited Chosun University Dental Hospital between June 1 and August 31, 2021. Enzyme-linked immunosorbent assay was conducted to measure the salivary cortisol concentration.
Results: The salivary cortisol concentration in the TMD patient group and the control group differed significant significantly (p<0.05). The salivary cortisol concentration according to the duration of the clinical symptom of TMD differed significantly difference between the two groups in the male. The salivary cortisol concentration according to perceived stress level differed significantly in the mild and moderate groups (p<0.05). There was no significant difference in salivary cortisol concentration between the two groups related to bruxism or clenching (p>0.05).
Conclusions: The salivary cortisol concentration in the TMD patient group and the control group showed statistical relevance, indicating that stress was a causative factor.

참고문헌 (Reference)

1 유지원 ; 윤창륙 ; 안종모, "스트레스와 관련된 구강안면통증의 연구에 있어서 타액내의 스트레스호르몬의 활용" 대한안면통증∙구강내과학회 32 (32): 201-210, 2007

2 Schiffman EL, "The relationship of occlusion, parafunctional habits and recent life events to mandibular dysfunction in a non-patient population" 19 : 201-223, 1992

3 Bassett JR, "The physiological measurement of acute stress(public speaking)in bank employees" 5 : 265-273, 1987

4 Kobayashi FY, "Salivary stress biomarkers and anxiety symptoms in children with and without temporomandibular disorders" 31 : e78-, 2017

5 Da Silva Andrade A, "Salivary cortisol levels in young adults with temporomandibular disorders" 57 : 109-116, 2008

6 Kirschbaum C, "Salivary cortisol in psychoneuroendocrine research : recent developments and applications" 19 : 313-333, 1994

7 Kirschbaum C, "Salivary cortisol in psychobiological research : an overview" 22 : 150-169, 1989

8 Hellhammer DH, "Salivary cortisol as a biomarker in stress research" 34 : 163-171, 2009

9 Jasim H, "Salivary cortisol and psychological factors in women with chronic and acute oro-facial pain" 41 : 122-132, 2014

10 Kahn JP, "Salivary cortisol : a practical method for evaluation of adrenal function" 23 : 335-349, 1988

11 Stahl F, "Responses of salivary cortisol levels to stresssituations" 80 : 158-162, 1982

12 천찬영 ; A-Hyang Yoon ; 안종모, "Relationship between self-reported bruxism and torus mandibularis of patients with temporomandibular disorders" 치의학연구원 43 (43): 136-140, 2019

13 Khayamzadeh M, "Relationship between parafunctional habits and salivary biomarkers" 16 : 465-472, 2019

14 Board F, "Psychological stress and endocrine functions; blood levels of adrenocortical and thyroid hormones in acutely disturbed patients" 18 : 324-333, 1956

15 Weibel L, "Methodological guidelines for the use of salivary cortisol as biological marker of stress" 32 : 845-851, 2003

16 Baum A, "Measuring stress: a guide for health and social scientists" Oxford University Press 175-192, 1995

17 Garde AH, "Long-term stability of salivary cortisol" 65 : 433-436, 2005

18 Salameh E, "Investigation of the relationship between psychosocial stress and temporomandibular disorder in adults by measuring salivary cortisol concentration : a case-control study" 15 : 148-152, 2015

19 O’Connor PJ, "Influence of short-term cycling on salivary cortisol levels" 19 : 224-228, 1987

20 Hofman LF, "Human saliva as a diagnostic specimen" 131 : 1621S-1625S, 2001

21 Jo JH, "Gender differences in clinical characteristics of Korean Temporomandibular Disorder patients" 11 : 3583-, 2021

22 Lehnen H, "Frontiers in stress research" Huber 392-394, 1989

23 Carlson CR, "Comparison of psychologic and physiologic functioning between patients with masticatory muscle pain and matched controls" 7 : 15-22, 1993

24 Lambert CA, "Chronic HPA axis response to stress in temporomandibular disorder" 87 : 73-81, 2013

25 Jae-Man Park ; 안종모, "Association between torus mandibularis, self-reported bruxism and occlusion" 치의학연구원 44 (44): 32-36, 2020

26 Alresayes S, "Assessment of self-rated pain perception and whole salivary cortisol levels among adolescents with and without temporomandibular disorders" 2021