라섹과 에피라식의 단기간 임상결과 분석 = Comparison of Short Term Clinical Results Between LASEK and Epi-LASIK

다국어 초록 (Multilingual Abstract)

`Purpose: To compare short-term clinical results of LASEK and epi-LASIK. Methods: Fifteen subjects (30 eyes) underwent uncomplicated LASEK on one eye and uncomplicated epi- LASIK on the other eye by a single surgeon, and uncorrected visual acuity, refractive change, postoperative pain, and postoperative satisfaction were compared at postoperative week one, at one month, and at three months. Results: Postoperative uncorrected visual acuities were 0.68±0.20, 0.96±0.22, and 1.05±0.17 for LASEK and 0.75±0.21, 0.92±0.14, and 1.01±0.21 for epi-LASIK at one week, one month, and three months, respectively. Epi-LASIK showed faster improvement in visual acuity at one week, while LASEK showed faster improvement afterward. However, no statistical significance was found. Spherical equivalet of LASEK was -0.66±1.28D and that of epi-LASIK was -0.61±0.92D at postoperative week one, implying faster refractive recovery for epi-LASIK, but after one month, LASEK was faster in refractive recovery and all these changes were not statistically significant. Durations of postoperative pain were 3.13±1.25 days for LASEK and 3.02±1.32 days for epi-LASIK. Pain scores (0~10 point scale), however, were also lower for LASEK by 0.33 point, 0.57 point, and 0.45 point for postoperative day 1, 2, and 3, respectively. No statistical significance was noted in either pain duration or pain score. When asked for overall satisfaction, six subjects preferred LASIK, four subjects preferred epi-LASIK, and five subjects showed no preference. Conclusions: Both LASEK and epi-LASIK are effective for surgical correction of myopia, and no significant difference in visual recovery, refractive change or degree of postoperative pain was noted in this study.`

참고문헌 (Reference)

1 Kim SY, "Twenty percent alcohol toxicity on rabbit corneal epithelial cells: electron microscopic study" 21 : 388-392, 2002

2 Kamm O, "The relation between structure and physiological action of the alcohols" 10 : 87-92, 1921

3 Kwon HL, "Short Term Clinical Results of Laser Epithelial Keratomileusis and epi-Laser in Situ Keratomileusis for Moderate and High Myopia" 10 : 1711-1717, 2005

4 O’ Doherty M, "Postoperative Pain Following epi-LASIK, LASEK, and PRK for Myopia" 23 : 133-138, 2007

5 Hersh PS, "Photorefractive keratectomy versus laser in situ keratomileusis for moderate to high myopia" 105 : 1513-1523, 1998

6 Seiler T, "Myopic photorefractive keratectomy with excimer laser: one-year follow-up" 98 : 1156-1163, 1991

7 Carones F, "Mechanical versus alcohol epithelial removal during photorefractive keratectomy" 15 : 556-562, 1999

8 Trokel SL, "Excimer laser surgery of the cornea" 96 : 710-715, 1983

9 Gartry DS, "Excimer laser photorefractive keratectomy: 18 months follow-up" 99 : 1209-1219, 1992

10 Pallikaris IG, "Epi-LASIK: Comparative histological evaluation of mechanical and alcohol- assisted epithelial separation" 29 : 1496-1501, 2003

11 Abad JC, "Dilute ethanol versus mechanical debridement before photorefractive keratectomy" 22 : 1427-1433, 1996

12 Seiler T, "Complications of myopic photorefractive keratectomy with the excimer laser" 101 : 153-160, 1994

13 Wang Z, "Comparison of laser in situ keratomileusis and photorefractive keratectomy to correct myopia from 1.25 to 6.00 diopters" 13 : 528-534, 1997

14 Lee JB, "Comparison of laser epithelial keratomileusis and photorefractive keratectomy for low to moderate myopia" 27 : 565-570, 2001

15 Kim HJ, "Clinical results of Laser epithelial keratomileusis and Laser in situ keratomileusis for moderate and high myopia" 44 : 1159-1164, 2003

16 Stein HA, "Alcohol removal of the epithelium for excimer laser ablation: outcomes analysis" 23 : 1160-1163, 1997

17 Lee SB, "Advanced Surface Ablation-Photorefractive Keratectomy (ASA-PRK): Safety and Clinical Outcome for the Correction of Mild to Moderate Myopia with a Thin Cornea" 47 : 1274-1286, 2006

18 Abad JC, "A prospective evaluation of alcohol-assisted versus mechanical epithelial removal before photorefractive keratectomy" 104 : 1566-1574, 1997