Sensory and motor axons are different: implications for neurological disease

다국어 초록 (Multilingual Abstract)

Using threshold tracking, differences have been established between large myelinated sensory and α motor axons in humans. Major differences are that sensory axons are relatively depolarised at rest such that they have a greater persistent Na+ current, and have greater activity of hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels. Sensory axons may thereby be protected from hyperpolarising stresses, and are less likely to develop conduction block. However, the corollary is that sensory axons are more excitable and more likely to become ectopically active.

참고문헌 (Reference)

1 Vogel W, "Voltage-clamp studies on axons: macroscopic and single-channel currents" Oxford University Press 257-280, 1995

2 Howells J, "The voltage dependence of Ih in human myelinated axons" 590 : 1625-1640, 2012

3 Grafe P, "The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons" 480 : 297-307, 1994

4 Inglis JT, "The development of conduction block in single human axons following a focal nerve injury" 513 : 127-133, 1998

5 Mogyoros I, "Strength-duration properties of human peripheral nerve" 119 : 439-447, 1996

6 Lin CS-Y, "Responses of human sensory and motor axons to the release of ischaemia and to hyperpolarizing currents" 541 : 1025-1039, 2002

7 Vallbo ÅB, "Prediction of propagation block on the basis of impulse shape in single unit recordings from human nerves" 97 : 66-74, 1976

8 Morita K, "Posttetanic hyperpolarization produced by electrogenic Na+-K+ pump in lizard axons impaled near their motor terminals" 70 : 1874-1884, 1993

9 Bostock H, "Post-tetanic excitability changes and ectopic discharges in a human motor axon" 117 : 913-928, 1994

10 Burke D, "Physiology of ALS and Related Disorders" Elsevier 43-53, 1997

11 Tatsumi H, "Na+ dependent Ca2+ influx induced by depolarization in neurons dissociated from rat nucleus basalis" 196 : 9-12, 1995

12 Kiernan MC, "Multiple measures of axonal excitability: a new approach in clinical testing" 23 : 399-409, 2000

13 Craner MJ, "Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+exchanger" 101 : 8168-8173, 2004

14 Bostock H, "Latent addition in motor and sensory fibres of human peripheral nerve" 498 (498): 277-294, 1997

15 Tomlinson S, "In vivo assessment of HCN channel current(Ih)in human motor axons" 41 : 247-256, 2010

16 Baker M, "Function and distribution of three types of rectifying channel in rat spinal root myelinated axons" 383 : 45-67, 1987

17 Vucic S, "Fatigue in multiple sclerosis : mechanisms and management" 121 : 809-817, 2010

18 Mogyoros I, "Excitability changes in human sensory and motor axons during hyperventilation and ischaemia" 120 : 317-325, 1997

19 Howells J, "Excitability and the safety margin in human axons during hyperthermia" 59 : 3063-3080, 2013

20 Kiernan MC, "Differences in the recovery of excitability in sensory and motor axons of human median nerve" 119 : 1099-1105, 1996

21 Bostock H, "Differences in behaviour of sensory and motor axons following release of ischaemia" 117 : 225-234, 1994

22 Kiernan MC, "Differences in activity-dependent hyperpolarization in human sensory and motor axons" 558 : 341-349, 2004

23 Kiernan MC, "Clinical evaluation of excitability measures in sensory nerve" 24 : 883-892, 2001

24 Kiernan MC, "Acute tetrodotoxin-induced neurotoxicity after ingestion of puffer fish" 57 : 339-348, 2005

25 Vagg R, "Activity-dependent hyperpolarization of human motor axons produced by natural activity" 507 : 919-925, 1998

26 Cappelen-Smith C, "Activity-dependent hyperpolarization and conduction block in chronic inflammatory demyelinating polyneuropathy" 48 : 826-832, 2000

27 Bostock H, "Activity-dependent excitability changes in normal and demyelinated rat spinal root axons" 365 : 239-257, 1985

28 Park SB, "Activity-dependent conduction failure : molecular insights" 16 : 159-168, 2011

29 Nodera H, "Activity-dependent conduction block in multifocal motor neuropathy: magnetic fatigue test" 67 : 280-287, 2006

30 Straver DC, "Activity-dependent conduction block in multifocal motor neuropathy" 43 : 31-36, 2011

31 Kaji R, "Activity-dependent conduction block in multifocal motor neuropathy" 123 : 1602-1611, 2000

32 Straver DC, "Activity-dependent conduction block in chronic inflammatory demyelinating polyneuropathy" 300 : 33-38, 2011

33 Howells J, "Accommodation to hyperpolarization of human axons assessed in the frequency domain" 116 : 322-335, 2016