Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans

다국어 초록 (Multilingual Abstract)

Brown adipose tissue (BAT) is a site of sympathetically activated non-shivering thermognenesis during cold exposure and after spontaneoushyperphagia, thereby involving in the autonomic regulation of energy balance and body fatness. Recent radionuclide studies have demonstratedthe existence of metabolically active BAT in adult humans. Human BAT is activated by acute cold exposure, particularly in winter, and contributesto cold-induced increase in whole-body energy expenditure. The metabolic activity of BAT is lower in older and obese individuals. Theinverse relationship between the BAT activity and body fatness suggests that BAT, because of its energy dissipating activity, is protective againstbody fat accumulation. In fact, either repeated cold exposure or daily ingestion of some food ingredients acting on transient receptor potentialchannels recruited BAT in association with increased energy expenditure and decreased body fatness. Thus, BAT is a promising target for combatingobesity and related metabolic disorders in humans.

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