Ultrasonographic Evaluation of the Endometrial Maturation in the Clomiphene Induced Menstrual Cycles

다국어 초록 (Multilingual Abstract)

The thrity-two clomiphene induced menstrual cycles were ultrasonographically monitored in order to evaluate the ultrasonographic phasic changes of uterine endometrial morphology and thickness with the follicular maturation (Dates: March, 1985 to February, 1986).
1. The ultrasonographic endometrial changes
The ultrasonographic endometrial changes in the early proliferative phase was characterized by a long thin endometrium which became much thicker, giving evidence of growth in endometrial glands and stroma. The stromal cells of the superficial layer may be separated by transduate which was ultrasonographically demonstrated by a hyporeflective area. Following ovulation, we observed the 'ring' sign as an indirect evidence of ovulation.
2. The endometrial thickness
The thickness of the central midline uterine echogenic area was 7.29 ± 1.63 ㎜ (Mean ± S.E.M.) in the early proliferative phase. These were 11.43 ± 1.38 ㎜, 11.85 ± 1.08 ㎜, 12.06 ± 1.39 ㎜, 12.52 ± 1.53 ㎜, 13.21 ± 1.81 ㎜, and 13.58 ± 1.61 ㎜, from Day -5 to Day 0 (= The day of ultrasonographic follicular rupture), respectively. It were also 13.66±2.09 ㎜ in the early secretory phase and 15.38±2.31 ㎜ in the late secretory phase, respectively.
3. The mid-luteal serum progesterone level
The mean serum level of the mid-luteal progesterone was 22.77±8.75 ng/ml.
We concluded that ultrasonographic monitoring of the endometrial morphology and thickness accompanying ovarian follicle monitoring is helpful in determining the endometrial dating as well as the confirmation of the progestational effect on the endometrial tissue and in detecting other organic pelvic disease related to infertility and menstrual disorders.