락탐화합물의 고리확장연구 : 입체선택성과 Mechanism에 관한 연구

다국어 초록 (Multilingual Abstract)

The ring expansion chemistry is one of the most important methods to prepare five- and six-membered hetero cyclic compounds.
we have studied about γ-lactam ring expansion with steroselectivity from β-lactam derivative. To do this chemistry, proton of N-benzyl group in β-lactam derivatives is eliminated by LDA and make carbanion. This anion make unstable 4-membered lactam intermediate, and then the ring is opened by homo cleavage or hetero cleavage for releasing ring strain, followed by recyclization to insert one carbon to make γ-lactam ring with stereoselectivity in β-, γ- positions.

목차 (Table of Contents)

• 목차
• List of Abbreviations = v
• 제I부 서론 = 1
• 제II부 결과 및 고찰 = 8
• 제III부 결론 = 22
• 제IV부 실험 = 23
• 제V부 참 고 문 헌 35
• 제VI부 부록 : IR, ¹H, ^13C-NMR Spectrum = 37
• ABSTRACT = 57