아마인유와 해바라기종자유의 혼합급이가 고지혈증 흰쥐의 신장지질의 지방산조성에 미치는 영향 = Effects of Feeding the Mixture of Linseed and Sunflower Seed oil on the Fatty acid Composition of Kidney lipid in Dietary Hyperlipidemic Rats

다국어 초록 (Multilingual Abstract)

This study was carried out to investigate the effect of feeding the mixture of linseed oil, rich in n-3 PUFA and the sunflower seed oil, rich in n-6 PUFA on the fatty acid composition in the dietary hyperlipidemic rats. After Male Sprague Dawley rats were induced hyperlipidemia by feeding the diet containing lard, butter and cholesterol for 3 weeks, then they were fed with the diet containing lard 3.0％ and sunflower seed oil and antihyperlipidenmic drugs for 2 weeks. Analysis of the lipid and the fatty acid composition of the kidney lipid showed following results.
In the total fatty acid contents of kidney lipids, monoenes were remarkedly lower than saturates and polyenes, while there were not significantly different among total diet groups. As compare to fatty acid contents of test lipid feed hyperlipidemic rats, Saturates and polyenes in the total fatty acid contents were increased, on the contrary, monoenes were getting significantly decreased In the fatty acid composition of phospholipid in kidney, polyenes contents were the most among all of them, especially C_(20:5)(n-5) was the major fatty acid. In the fatty acid composition of TG and cholestrryl ester, monoenes and saturates content were similar, but polyenes content were remarkedly low as 7.0-25.8％ since C_(20:0), C_(22:5)(n-6), C_(22:5)(n-6), C_(22:6)(n-3) were not distributed Polyenes contents of group 5-9 feed mixed linseed oil and sunflower oil were getting higher than group 1-4 feed butter or olive oil in the TG and cholesteryl ester, and it seems to be affected by the fatty acid composition of the test lipids. C_(20:5)(n-3) was the major fatty acid and PL, while C_(18:2)(n-6) was the major fatty acid in TG and cholesteryl ester of kidney lipid Each lipid composition was comparatively influenced by test lipid rather than cholestyramine and antihyperlipidemic dose. Sunflower seed oil and linseed oil were effective for the improvement of kidney lipids.