전립선수술에 대한 예방적 항생제요법 = Antimicrobial Prophylaxis for Prostatic Surgery

다국어 초록 (Multilingual Abstract)

Antimicrobial prophylaxis is the periprocedural systemic administration of an antimicrobial agent intended to reduce the risk of postprocedural local and systemic infection. However, the use of antibiotics in urologic surgery has been controversial for decades. Significant progress in prostate surgery was made during the previous decade, however, controversy over antibiotic prophylaxis for prostatic surgery remains. In the context of surgical field classification, transurethral resection of the prostate and radical prostatectomy can be categorized according to a clean-contaminated operation. Therefore, in this regard, administration of prophylactic antibiotics is appropriate for prevention of postoperative infectious complications. Unfortunately, however, studies of the prophylactic effect of antimicrobial therapy with prostatic surgery have been limited. There is currently a lack of information on the risk factors for infectious complications associated with prostate surgery in Korea. In addition, the Korean National Health Insurance System recently recommended the use of current guidelines for surgical site infection focusing on gastrointestinal surgery, not urinary tract infection in patients undergoing prostate surgery without any Korean evidence. Because many urological procedures are associated with urine exposure and endourological procedures, these guidelines cannot be adapted to urologic prostatic surgery. In open or laparoscopic prostatic surgery (radical prostatectomy or prostatectomy), the urinary tract is opened during the procedure; thus, postoperative bacteriuria is probably the main source of postoperative infectious complications.

참고문헌 (Reference)

1 유광호, "최근 요로감염증의 주요 원인균과 항생제 감수성에 관한 고찰" 대한비뇨기과학회 48 (48): 638-645, 2007

2 Bratzler DW, "Use of antimicrobial prophylaxis for major surgery : baseline results from the National Surgical Infection Prevention Project" 140 : 174-182, 2005

3 Bates T, "Timing of prophylactic antibiotics in abdominal surgery:trial of a pre-operative versus an intra-operative first dose" 76 : 52-56, 1989

4 Classen DC, "The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection" 326 : 281-286, 1992

5 Bergamini TM, "The importance of tissue antibiotic activity in the prevention of operative wound infection" 23 : 301-313, 1989

6 Kirkland KB, "The impact of surgical-site infections in the 1990s : attributable mortality, excess length of hospitalization, and extra costs" 20 : 725-730, 1999

7 Burke JF, "The effective period of preventive antibiotic action in experimental incisions and dermal lesions" 50 : 161-168, 1961

8 Sakura M, "Prospective comparative study of single dose versus 3-day administration of antimicrobial prophylaxis in minimum incision endoscopic radical prostatectomy" 15 : 328-331, 2008

9 Berry A, "Prophylactic antibiotic use in transurethral prostatic resection : a meta-analysis" 167 : 571-577, 2002

10 Kahlmeter G, "Prevalence and antimicrobial susceptibility of pathogens in uncomplicated cystitis in Europe. The ECO.SENS study" 22 (22): 49-52, 2003

11 Grabe M, "Preoperative assessment of the patient and risk factors for infectious complications and tentative classification of surgical field contamination of urological procedures" 30 : 39-50, 2012

12 Grabe M, "Perioperative antibiotic prophylaxis in urology" 11 : 81-85, 2001

13 Kunin CM, "Nosocomial urinary tract infections and the indwelling catheter: what is new and what is true?" 120 : 10-12, 2001

14 "National Nosocomial Infections Surveillance (NNIS) report, data summary from October 1986-April 1996, issued May 1996. A report from the National Nosocomial Infections Surveillance (NNIS) System" 24 : 380-388, 1996

15 Matsumoto T, "Japanese guidelines for prevention of perioperative infections in urological field" 14 : 890-909, 2007

16 Grabe M, "Guidelines on urological infections" 76-90, 2013

17 Mangram AJ, "Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee" 20 : 250-278, 1999

18 Naber KG, "EAU guidelines for the management of urinary and male genital tract infections" 40 : 576-588, 2001

19 Lee SJ, "Current status of antimicrobial resistance among bacterial pathogens causing urinary tract infection in Korea" 4 : 37-46, 2009

20 Grabe M, "Controversies in antibiotic prophylaxis in urology. Int J Antimicrob Agents" 23 (23): S17-S23, 2004

21 Takeyama K, "Comparison of 1-day, 2-day, and 3-day administration of antimicrobial prophylaxis in radical prostatectomy" 13 : 320-323, 2007

22 Wolf JS Jr, "Best practice policy statement on urologic surgery antimicrobial prophylaxis" 179 : 1379-1390, 2008

23 Childs SJ, "Appropriate surgical prophylaxis in transurethral genitourinary surgery and potential reduction in nosocomial infections" 27 : 415-420, 1986

24 "Antimicrobial prophylaxis in surgery" 43 : 92-97, 2001

25 Taoka R, "Antimicrobial prophylaxis in radical prostatectomy : single dose versus 1-day treatment" 56 : 559-563, 2010

26 Page CP, "Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care" 128 : 79-88, 1993

27 Bratzler DW, "Antimicrobial prophylaxis for surgery : an advisory statement from the National Surgical Infection Prevention Project" 38 : 1706-1715, 2004

28 Bratzler DW, "Antimicrobial prophylaxis for surgery : an advisory statement from the National Surgical Infection Prevention Project" 189 : 395-404, 2005

29 "Antimicrobial prophylaxis for surgery" 2 : 27-32, 2004

30 Çek M, "Antibiotic prophylaxis in urology departments, 2005-2010" 63 : 386-394, 2013

31 Bootsma AM, "Antibiotic prophylaxis in urologic procedures : a systematic review" 54 : 1270-1286, 2008

32 Terai A, "Antibiotic prophylaxis in radical prostatectomy : 1-day versus 4-day treatments" 13 : 1488-1493, 2006

33 Qiang W, "Antibiotic prophylaxis for transurethral prostatic resection in men with preoperative urine containing less than 100, 000bacteria per ml : a systematic review" 173 : 1175-1181, 2005

34 Sabbagh R, "A prospective randomized trial of 1-day versus 3-day antibiotic prophylaxis for transrectal ultrasound guided prostate biopsy" 11 : 2216-2219, 2004