RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      Restoration ofT-box-containing protein expressed in T cells protects against allergen-induced asthma

      한글로보기

      https://www.riss.kr/link?id=A99794072

      • 저자

        Eun Sook, Hwang (The College of Pharmacy and Division of Life and Pharmaceutical Sciences and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul) ;  Jung Won, Park (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.) ;  Hyun Jung, Min (The College of Pharmacy and Division of Life and Pharmaceutical Sciences and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul) ;  Jung Ho, Sohn (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.) ;  Joo Young, Kim (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.) ;  Jeong Ho, Hong (the Department of Medicine, Harvard Medical School, Boston) ;  Kirsten S. Sigrist (the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston) ;  Laurie H. Glimcher (the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston)

      • 발행기관
      • 학술지명
      • 권호사항
      • 발행연도

        2010

      • 작성언어

        English

      • 주제어
      • 자료형태

        학술저널

      • 수록면

        32-44(13쪽)

      • 제공처
      • 중단사유

        ※ 저작자의 요청에 따라 해당 논문은 원문이 제공되지 않습니다.

      • 소장기관
      • ※ 대학의 dCollection(지식정보 디지털 유통체계)을 통하여 작성된 목록정보입니다.
      • 0

        상세조회
      • 0

        다운로드
      서지정보 열기
      • 내보내기
      • 내책장담기
      • 공유하기
      • 오류접수

      부가정보

      다국어 초록 (Multilingual Abstract)

      BACKGROUND:

      A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T(H) cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce T(H)2 cytokines and have spontaneous airway inflammation.

      OBJECTIVES:

      We tested whether T-bet overexpression could protect against the development or progression of asthma.

      METHODS:

      We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model.

      RESULTS:

      Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T(H)2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T(H)2 cytokine production.

      CONCLUSIONS:

      Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma.
      번역하기

      BACKGROUND: A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T(H) cell differentiation by means of distinct mechanisms. T-bet-deficient mice ...

      BACKGROUND:

      A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T(H) cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce T(H)2 cytokines and have spontaneous airway inflammation.

      OBJECTIVES:

      We tested whether T-bet overexpression could protect against the development or progression of asthma.

      METHODS:

      We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model.

      RESULTS:

      Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T(H)2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T(H)2 cytokine production.

      CONCLUSIONS:

      Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma.

      더보기

      분석정보

      View

      상세정보조회

      0

      Usage

      원문다운로드

      0

      대출신청

      0

      복사신청

      0

      EDDS신청

      0

      동일 주제 내 활용도 TOP

      더보기

      주제

      연도별 연구동향

      연도별 활용동향

      연관논문

      연구자 네트워크맵

      공동연구자 (7)

      유사연구자 (20) 활용도상위20명

      이 자료와 함께 이용한 RISS 자료

      나만을 위한 추천자료

      해외이동버튼