Skin Whitening Activity of Supercritical Fluid Extract from Spent Coffee in B16F10 Melanoma Cell

다국어 초록 (Multilingual Abstract)

In the present study, we evaluated the skin whitening effects of supercritical fluid extract (SFE) of the spent coffee (SC) on tyrosinase inhibition activity, melanin synthesis inhibition activity and DOPA staining. Hot water extracts from coffee bean (CB) and SC and drip extracts from CB were employed for control. Inhibitions of melanin activities of SFE (SC) at short processing time were significantly higher than other values under the same extract processing. In comparison, inhibition of melanin activities appeared at high pressure in CB. Tyrosinase inhibition activity of SFE (SC) extracted for 1 h at 150 bar was significantly higher than those of SFE (CB and SC) even of controls. According to the above results, SFE (SC) extracted for 2 h or less at 450 bar showed significantly high activities in the melanin synthesis inhibition and tyrosinase inhibition.

참고문헌 (Reference)

1 김관중, "커피 원두의 배전공정중 변화되는 주요 화학성분에 대한 연구" 한국식품과학회 38 (38): 153-158, 2006

2 진종언, "지치(Lithospermum erythrorhizon) 추출물의 멜라닌 생합성 억제효과" 한국식품영양과학회 34 (34): 1325-1329, 2005

3 조은정, "야관문 잎 페놀 추출물의 항산화능 및 미백 효과" 한국원예학회 29 (29): 358-365, 2011

4 석귀덕, "새삼(Cuscuta japonica Choisy)및 실새삼(C. australis R.Be) 추출물의 Mushroom Tyrosinase 활성 억제 효과" 한국생약학회 35 (35): 380-383, 2004

5 김수경, "삼백초 약침액이 B16F10 흑색종세포의 멜라닌 합성에 미치는 영향" 경락경혈학회 29 (29): 117-130, 2012

6 임영미, "배양 인체피부섬유모세포에 있어서 활성산소의 산화적 손상에 대한 山査추출물의 항산화 효과" 한의병리학회 22 (22): 115-119, 2008

7 조유나, "가지 외피 에탄올 추출물의 피부보호효과" 한국식품과학회 44 (44): 94-99, 2012

8 Aida K, "Up and down regulation of melanin production of mouse melanoma B16C7 cells with fatty acid" 47 : 793-796, 2000

9 Maqid AA, "Tyrosinase inhibitos and sesquiterpene diglycosides from Guioa villosa" 74 : 55-60, 2008

10 Silva MA, "The use of biomass residues in the brazilian soluble coffee industry" 14 : 457-467, 1998

11 Urabe K, "The inherent cytotoxicity of melanin precursors: A revision" 1221 : 272-278, 1994

12 Kim KJ, "Supercritical fluid technology for green food processing" 43 : 35-52, 2010

13 Couto RM, "Supercritical fluid extraction of lipids from spent coffee grounds" 51 : 159-166, 2009

14 Kim HB, "Studies on enhancement functional substances in coffee by supercritical fluid extraction" Ajou University 2007

15 Itoh T, "Sterol composition of 19 vegetable oils" 50 : 122-125, 1973

16 Jung SW, "Screening of tyrosinase inhibitior from plants" 27 : 891-896, 1995

17 Hosoi J, "Regulation of melanin synthesis of B16 mouse melanoma cells by 1α, 25-dihydroxyvitamin D3 and retinoic acid" 45 : 1474-1478, 1985

18 Martínez-Esparza M, "Mechanisms of melanogenesis inhibition by tumor necrosis factor-alpha in B16/F10 mouse melanoma cells" 255 : 139-146, 1998

19 Chen JS, "Marshall MR. Inhibition mechamism of kojic acid on polyphenol oxidase" 39 : 1897-1901, 1991

20 Roura E, "Lamuela-Raventós RM. Total polyphenol intake estimated by a modified Folin-Ciocalteu assay of urine" 52 : 749-752, 2006

21 Cabanes J, "Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase" 46 : 982-985, 1994

22 Zheng ZP, "Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent" 52 : 1530-1538, 2008

23 Arung ET, "Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis" 29 : 1966-1969, 2006

24 Jeon HJ, "Identification and kinetic study of tyrosinase inhibitors found in sake lees" 54 : 9827-9833, 2006

25 MFDS, "Food Standards Codex. Method 9"

26 Cooksey CJ, "Evidence of the indirect formation of the catecholic intermediate substrate responsible for the autoactivation kinetics of tyrosinase" 272 : 26226-26235, 1997

27 Buscà R, "Cyclic AMP a key messenger in the regulation of skin pigmentation" 13 : 60-69, 2000

28 Borrelli RC, "Chemical characterization and antioxidant properties of coffee melanoidins" 50 : 6527-6533, 2002

29 Bell AA, "Biosynthesis and function of fungal melanin" 24 : 411-451, 1986

30 Saha B, "Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB" 19 : 595-605, 2006