유산소성 운동 강도의 차이가 산화적-질소적 스트레스 및 뇌신경세포 생성인자에 미치는 영향 = Effects of Aerobic Exercise Intensities on Neurotrophic Factor and Oxidative-Nitrosative Stress

다국어 초록 (Multilingual Abstract)

The purpose of the current research is to investigate the effects of different aerobic exercise intensities on neurotrophic factor induced by oxidative-nitrosative stress. The subjects of the current research were 15 healthy male. The subjects were asked to perform treadmill running in three different conditions: 1) low-intensity exercise(LIE, 50%VO₂max), 2) moderate-intensity exercise(MIE, 65%VO₂max), and 3) high-intensity exercise(HIE, 85%VO₂max). Blood sampling were taken at rest, at immediately after-exercise, and at 60minute after-exercise for examining the levels of oxidative-nitrosative stress markers[malonaldehyde(MDA), nitrite, superoxide dismutase(SOD)] and neurotrophic factor[glial cell line-derived neurotrophic factor(GDNF), insulin like growth factor-1 (IGF-1)]. The result of current research shows that the levels of MDA, nitrite, SOD, GDNF and IGF-1 were significantly increased after acute aerobic exercise(p〈.05). and the levels of MDA, nitrite, SOD appeared to be significantly higher in HIE compared to LIE and/or MIE(p〈.05). These results suggest that acute aerobic exercise can induce increase responses of oxidative-nitrosative stress and neurotrophic factor. It is suggested, however, that high intensity exercise could increase the oxidative-nitrosative stress.

목차 (Table of Contents)

• Abstract
• Ⅰ. 서론
• Ⅱ. 연구방법
• Ⅲ. 결과
• Ⅳ. 논의
• Ⅴ. 결론
• 참고문헌

참고문헌 (Reference)

1 노희태, "탈진적 운동이 혈중 BDNF, IGF-1 농도 및 인지 기능에 미치는 영향" 한국사회체육학회 (45) : 969-978, 2011

2 전태원, "최대하 운동의 강도에 따른 혈중 지질 과산화와 항산화 효소 활성의 변화" 한국운동생리학회 13 (13): 413-422, 2004

3 권광준, "청소년기 ICR 생쥐에서 비선택적 산화질소 생성 효소 억제제인 L-NAME이 구속 스트레스 후의 행동양식과 해마에서의 GDNF 발현에 미치는 영향" 대한정신약물학회 23 (23): 5-10, 2012

4 오명진, "척수 편측절단 손상 후 일회성 운동량에 따른 neurotrophins 단백질발현 및 수용체 활성" 한국운동생리학회 20 (20): 475-486, 2011

5 백일영, "운동과 에너지대사" 대한미디어 2006

6 김영일, "운동과 뇌신경성장인자(BDNF)에 대한 고찰: 일회성 유산소 · 저항성 운동과 규칙적인 유산소 · 저항성 트레이닝 중심으로" 한국사회체육학회 (52) : 663-674, 2013

7 윤진환, "운동강도의 차이가 노화된 F344흰쥐 해마의 치상회에서 신경세포 생성과 항산화효소에 미치는 영향(Ⅱ)" 한국발육발달학회 13 (13): 83-93, 2005

8 이윤미, "운동강도에 따른 MDA와 SOD의 변화" 한국운동영양학회 12 (12): 83-88, 2008

9 엄우섭, "운동강도에 따른 12주간 유산소성 운동이 지질 과산화물(MDA)과 항산화 효소(SOD)에 미치는 영향" 한국운동생리학회 13 (13): 355-350, 2004

10 정한영, "운동 강도에 따른 성장호르몬, IGF-1의 변화" 한국체육과학회 15 (15): 587-598, 2006

11 조수연, "고강도 운동 시 성별에 따른 혈장 MDA, SOD 및 임파구 DNA 손상 변화" 한국생명과학회 21 (21): 838-844, 2011

12 Khan, N.A., "The relation of childhood physical activity and aerobic fitness to brain function and cognition" 26 (26): 138-146, 2014

13 Huang, T., "The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans" 24 (24): 1-10, 2014

14 Schmolesky, M. T., "The effects of aerobic exercise intensity and duration on levels of brainderived neurotrophic factor in healthy men" 12 (12): 502-511, 2013

15 Ferris, L. T., "The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function" 39 (39): 728-734, 2007

16 Powers, S. K., "Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle" 589 (589): 2129-2138, 2011

17 Fisher-Wellman, K., "Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders" 2 (2): 43-51, 2009

18 Moshage, H., "Nitrite and nitrate determinations in plasma : a clinical evaluation" 41 : 892-896, 1995

19 구억, "Nitric oxide에 의해 산화적 스트레스를 받은 Neuronal cell에 항산화 효과를 가지는 수종 생약추출물의 검색" 한국생약학회 39 (39): 290-294, 2008

20 Castillo, J., "Nitric oxide-related brain damage in acute ischemic stroke" 31 (31): 852-857, 2000

21 Chabrier, P. E., "Nitric oxide synthases:targets for therapeutic strategies in neurological diseases" 55 (55): 1029-1035, 1999

22 Moretto, M., "Nitric oxide regulates luteinizing hormone-releasing hormone secretion" 133 (133): 2399-2402, 1993

23 Yasin, S., "Nitric oxide modulates the release of vasopressin from rat hypothalamic explants" 133 (133): 1466-1469, 1993

24 Shibata, M., "Nitric oxide modulates oxygen consumption by arteriolar walls in rat skeletal muscle" 289 (289): 2673-2679, 2005

25 Kam, P. C., "Nitric oxide : basic science and clinical applications" 49 : 515-521, 1994

26 Götz, R., "Neurotrophin-6 is a new member of the nerve growth factor family" 372 (372): 266-269, 1994

27 Alberch, J., "Neurotrophic factors in Huntington's disease" 146 : 195-229, 2004

28 Knott, A. B., "Mitochondrial fragmentation in neurodegeneration" 9 (9): 505-518, 2008

29 McCarthy, C. G., "High-fat f eeding, b ut n ot s trenuous e xercise, increases blood oxidative stress in trained men" 38 (38): 33-41, 2013

30 Valko, M., "Free radicals and antioxidants in normal physiological functions and human disease" 39 (39): 44-84, 2007

31 Zigmond, M., "Foreword: exercise and the brain" 1341 : 1-2, 2010

32 Bruce, R. A., "Exercising testing in adult normal subjects and cardiac patients" 32 (32): 742-756, 1963

33 Alessio, H. M., "Exercise-induced oxidative stress" 25 (25): 218-224, 1993

34 Kradin, R., "Endothelial nitric oxide synthase expression in pulmonary capillary hemangiomatosis" 79 (79): 194-197, 2005

35 Valado, A., "Effect of the intense anaerobic exercise on nitric oxide and malondialdehyde in studies of oxidative stress" 1 (1): 32-36, 2007

36 Rojas Vega, S., "Effect of resistance exercise on serum levels of growth factors in humans" 42 (42): 982-986, 2010

37 Bloomer, R. J., "Effect of exercise on oxidative stress biomarkers" 46 : 1-50, 2008

38 Goto, C., "Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium- dependent nitric oxide and oxidative stress" 108 (108): 530-535, 2003

39 Cappon, J., "Effect of brief exercise on circulating insulin-like growth factor I" 76 (76): 2490-2496, 1994

40 Poveda, J. J., "Contribution of nitric oxide to exercise-induced changes in healthy volunteers: effects of acute exercise and long-term physical training" 27 (27): 967-971, 1997

41 Carro, E., "Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy" 21 : 5678-5684, 2001

42 Carro, E., "Circulating insulin-like growth factor I mediates effects of exercise on the brain" 20 : 2926-2933, 2000

43 R. Lovlin, R., "Are indices of free radical damage related to exercise intensity" 56 (56): 313-316, 1987

44 Deak, F., "Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1" 67 (67): 611-625, 2012

45 Reeve, A. K., "Age related mitochondrial degenerative disorders in humans" 3 (3): 750-756, 2008

46 Schwarz, A. J., "Acute effect of brief low-and high-intensity exercise on circulating insulin-like growth factor(IGF)I, I I, a nd I GF-b niding p rotein-3 a nd its proteolysis in young healthy men" 81 (81): 3492-3497, 1996

47 Keeler, B. E., "Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury" 1438 : 8-21, 2012

48 McDonnell, M. N., "A single bout of aerobic exercise promotes motor cortical neuroplasticity" 114 (114): 1174-1182, 2013