Penicillamine-induced virginal mammary hypertrophy

다국어 초록 (Multilingual Abstract)

Virginal mammary hypertrophy (VMH), also known as juvenile mammary hypertrophy, is characterized by excessive enlargement of the breasts. Especially in adolescent patients, this condition can cause a negative body image to develop and result in significant psychological stress. Furthermore, social problems can arise from difficulties in finding appropriately-fitting attire and having trouble exercising. Although the mechanism of VMH has not been fully elucidated, several associated drugs have been identified. In this report, we present a 15-year-old female patient with Wilson disease who developed macromastia after administration of penicillamine for 8 months. Despite cessation of penicillamine for 3 months, the condition remained stable; thus, reduction mammoplasty was performed. After surgery, the patient was able to return to activities of daily living. Although rare, physicians should be aware of the fact that penicillamine can cause VHM. Therefore, patients with Wilson disease should be checked regularly for changes in breast volume in order to minimize possible complications.

참고문헌 (Reference)

1 O’Hare PM, "Virginal breast hypertrophy" 17 : 277-281, 2000

2 Taylor PJ, "Successful treatment of Dpenicillamine-induced breast gigantism with danazol" 282 : 362-363, 1981

3 Brewer GJ, "Recognition, diagnosis, and management of Wilson’s disease" 223 : 39-46, 2000

4 Munro R, "Penicillamine" 36 : 104-109, 1997

5 Rose BI, "Macromastia in a woman treated with penicillamine and oral contraceptives : a case report" 35 : 43-45, 1990

6 Fisher W, "Macromastia during puberty" 47 : 445-451, 1971

7 Cruz NI, "Lactational performance after breast reduction with different pedicles" 120 : 35-40, 2007

8 Wolfswinkel EM, "Hyperplastic breast anomalies in the female adolescent breast" 27 : 49-55, 2013

9 Sakai Y, "Gigantomastia induced by bucillamine" 49 : 193-195, 2002

10 Dancey A, "Gigantomastia : a classification and review of the literature" 61 : 493-502, 2008

11 Desautels JE, "Breast gigantism due to D-penicillamine" 45 : 143-144, 1994