기관지 천식에 대한 면역치료의 효과 : 임상증상, 말초혈액호산구수, 피부반응검사, 혈청내특이 IgE치, 히스타민 유발시험 및 세포성면역반응의 변화 Changes of Clinical Symptoms, Peripheral Eosinophil Counts, Allergen Skin Test, Specific IgE Levels, Histamine Provocation Test(HPT), and Cell Mediated Immunity = Effect of Immunotherapy in Bronchial Asthma

다국어 초록 (Multilingual Abstract)

The changes of symptom grade, peripheral eosinophil counts, specific IgE levels, allergen skin test, histamine provocation test(HPT), and cell mediated immunity before and during immunotherapy were observed in 36 bronchial asthmatics and 10 healthy persons. Immunotherapy was performed with "SDV, HDM, Alavac-SHDM, I.e., mistures of multiple allergens specific for each patient. The clinical grade was improved by immunotherapy. The peripheral eosinophil counts significantly decreased by immunotherapy, but no significant difference was observed among the 6month-1 year, or over 3 years groups.
The wheal size measured by prick test with specific allergens decreased by immunotherapy, but no statistically significant difference was observed among each group. All specific IgE levels measured by RAST showed either equal or decreased levels compared with the initial level of specific IgE measured before immunotherapy.
When HPT was performed with histamine at a concentration of 2mg/ml and 5mg/ml, no treatment group among bronchial asthmatics showed a higher positive rate and progressively decreased during immunotherapy. The mean antigen score obtained by Multitest CMI skin test for cell mediated immunity showed no significant differences among healthy, preimmunotherapy, and immunotherapy groups.