소아 그레이브스병에서 부신호르몬 및 IgE의 변화 = A Change of Adrenal Androgen, Cortisol, and IgE in Children with Graves' Diseases

다국어 초록 (Multilingual Abstract)

Graves' disease is a autoimmune thyroid disease. In pathogenesis of Graves' disease, T cell is known as that helps production of thyroid autoantibodies. Endocrine and immune systems are connected and interdependent. Adrenal gland plays an important role in this network and control the balance between serum levels of dehydroepiandrosterone sulfate(DHEAS) and cortisol. The authors evaluated the change of adrenal androgen, cortisol and immunoglobulin E as immune modulators in Graves' disease. From March, 1999 to August, 2002, Serum DHEAS, 24 hour urine free cortisol(F) and IgE and thyroid autoantibodies(TsAb, TBII, AMA, ATA) examined in 22 Graves' patients Serum IgE increased in 41.2% of all patients(97.41±99.07IU/mL). DHEAS was increased in only 5.5% of all patients, and it was decreased or included in normal range in 94.5% of patients(99.3±91.49μg/dL). DHEAS was correlated with ATA(r=0.517).Twenty-four hour urine free cortisol was increased in 72.2% of patients(64.45±47.59μg/dL), but it had no interrelationship with thyroid autoantibodies. Ratio of DHEAS/F had 2.08±2.06, and it had negative correlation with TsAb and TBII, respectively(r=-0.487, r=-0.565).
These data demonstrate that there are change of adrenal hormones(DHEAS and cortisol) and IgE, and dis-equilibrium between two adrenal hormones in children with Graves' disease, and Thse might be some relevant to the T cell immune response induction of Graves' disease.