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      Aflatoxin B_1과 Vitamin A가 發生中인 白鼠의 肝에 미치는 影響 = The Effect of Aflatoxin B_1 & Vitamin A on the Developing Fetal Rat Liver

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      https://www.riss.kr/link?id=A19592184

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      For the study on the effect of aflatoxin B_1 and vitamnin A on the developing fetal rat liver, aflatoxin B_1(1mg/kg, Sigma Chemicals) was administered intraperitoneally on the 8th day of pregnancy and vitamin A (50,000IU/day, Sigma Chemicals) was administered orally from the 8th day of pregnancy to a day before sacrifice daily. Under ether anesthesia, removed uterus, opened the pregnant sac, and fetuses were fixed in the 10% neutral buffered formalin solution. The 5㎛ thick liver specimens were stained with H-E and the mitotic figures were counted under high power field(x400) of light microscope.
      The results were as followings:
      1. Aflatoxin B_1 inhibited the liver cell mitosis.
      2. On the 14th day of development, vitamin A inhibited the antimitotic effect of aflatoxin B_1.
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      For the study on the effect of aflatoxin B_1 and vitamnin A on the developing fetal rat liver, aflatoxin B_1(1mg/kg, Sigma Chemicals) was administered intraperitoneally on the 8th day of pregnancy and vitamin A (50,000IU/day, Sigma Chemicals) was admi...

      For the study on the effect of aflatoxin B_1 and vitamnin A on the developing fetal rat liver, aflatoxin B_1(1mg/kg, Sigma Chemicals) was administered intraperitoneally on the 8th day of pregnancy and vitamin A (50,000IU/day, Sigma Chemicals) was administered orally from the 8th day of pregnancy to a day before sacrifice daily. Under ether anesthesia, removed uterus, opened the pregnant sac, and fetuses were fixed in the 10% neutral buffered formalin solution. The 5㎛ thick liver specimens were stained with H-E and the mitotic figures were counted under high power field(x400) of light microscope.
      The results were as followings:
      1. Aflatoxin B_1 inhibited the liver cell mitosis.
      2. On the 14th day of development, vitamin A inhibited the antimitotic effect of aflatoxin B_1.

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