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      상황버섯균사체배양액에 침지한 발아현미의 항산화 및 nitric oxide 합성저해에 관한 연구 = Studies on Antioxidant Activity and Inhibition of Nitric Oxide Synthesis of Germinated Brown Rice Soaked in Mycelial Culture Broth of Phellinus linteus

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      https://www.riss.kr/link?id=A103756272

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      다국어 초록 (Multilingual Abstract)

      This study investigated the effects on the biological activities of germinated brown rice soaked in mycelial culture broth of Phellinus linteus. The level of free amino acid was higher in the GBRP extract than those of BR and GBR. The major free amino acids were alanine, valine, isoleucine and methionine in both extracts. The level of ${\gamma}$-aminobutyric acid (GABA) was also increased significantly in the GBR and GBRP. Antioxidant activities of methanol extract of BR, GBR and GBRP were measured by using DPPH radical scavenging and SOD-like activity. Antioxidant activities showed the highest level of 83% and 76% when 100 mg/ml GBR and GBRP, respectively. Stimulation of the macrophages RAW264.7 cells with lipopolysaccharide (LPS) resulted in increased production of nitric oxide (NO) in the medium. However, the methanol extract of GBR and GBRP showed marked inhibition of NO synthesis in a does-dependant manner. These results showed that GBR and GBRP were significant role for activation of immune system in the pathogenesis of inflammatory diseases.
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      This study investigated the effects on the biological activities of germinated brown rice soaked in mycelial culture broth of Phellinus linteus. The level of free amino acid was higher in the GBRP extract than those of BR and GBR. The major free amino...

      This study investigated the effects on the biological activities of germinated brown rice soaked in mycelial culture broth of Phellinus linteus. The level of free amino acid was higher in the GBRP extract than those of BR and GBR. The major free amino acids were alanine, valine, isoleucine and methionine in both extracts. The level of ${\gamma}$-aminobutyric acid (GABA) was also increased significantly in the GBR and GBRP. Antioxidant activities of methanol extract of BR, GBR and GBRP were measured by using DPPH radical scavenging and SOD-like activity. Antioxidant activities showed the highest level of 83% and 76% when 100 mg/ml GBR and GBRP, respectively. Stimulation of the macrophages RAW264.7 cells with lipopolysaccharide (LPS) resulted in increased production of nitric oxide (NO) in the medium. However, the methanol extract of GBR and GBRP showed marked inhibition of NO synthesis in a does-dependant manner. These results showed that GBR and GBRP were significant role for activation of immune system in the pathogenesis of inflammatory diseases.

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      참고문헌 (Reference)

      1 이흠숙, "현미의 발아정도에 의한 항산화활성의 변화" 한국식품영양과학회 35 (35): 389-394, 2006

      2 최희돈, "전처리 조건이 현미 및 발아현미의 g-aminobutyric acid 함량에 미치는 영향" 한국식품과학회 36 (36): 761-764, 2004

      3 이경환, "상황버섯(Phellinus linteus) 추출물의 생리활성" 한국응용생명화학회 49 (49): 298-303, 2006

      4 박종대, "발아시킨 현미의 품질특성" 한국식품저장유통학회 11 (11): 182-188, 2004

      5 Crawford, L. A., "The synthesis of γ-aminobutyric acid in response to treatments reducing cytosolic pH" 104 : 865-871, 1994

      6 Brown, A. W, "The mechanism and functions of γ-aminobutyric acid" 115 : 1-5, 1997

      7 Park, D. K., "Study on immunomodulatory activity of Phellinus lintus grown on germinated brown rice" Konkuk Univ. 2005

      8 Choi, J. H., "Studies on the main factors affecting the mycelial growth of Phellinus linteus" 24 : 214-222, 1996

      9 Kim, D. H., "Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus" 18 : 295-303, 1996

      10 Choi, J. H., "Quality characteristics of the bread with sprouted brown rice flour" 17 : 323-328, 2001

      1 이흠숙, "현미의 발아정도에 의한 항산화활성의 변화" 한국식품영양과학회 35 (35): 389-394, 2006

      2 최희돈, "전처리 조건이 현미 및 발아현미의 g-aminobutyric acid 함량에 미치는 영향" 한국식품과학회 36 (36): 761-764, 2004

      3 이경환, "상황버섯(Phellinus linteus) 추출물의 생리활성" 한국응용생명화학회 49 (49): 298-303, 2006

      4 박종대, "발아시킨 현미의 품질특성" 한국식품저장유통학회 11 (11): 182-188, 2004

      5 Crawford, L. A., "The synthesis of γ-aminobutyric acid in response to treatments reducing cytosolic pH" 104 : 865-871, 1994

      6 Brown, A. W, "The mechanism and functions of γ-aminobutyric acid" 115 : 1-5, 1997

      7 Park, D. K., "Study on immunomodulatory activity of Phellinus lintus grown on germinated brown rice" Konkuk Univ. 2005

      8 Choi, J. H., "Studies on the main factors affecting the mycelial growth of Phellinus linteus" 24 : 214-222, 1996

      9 Kim, D. H., "Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus" 18 : 295-303, 1996

      10 Choi, J. H., "Quality characteristics of the bread with sprouted brown rice flour" 17 : 323-328, 2001

      11 Oh, S. H., "Production of the quality germinated brown rices containing high γ-aminobutyric acid by chitosan application" 15 : 615-620, 2000

      12 Juliano, B. O., "Production and utilization of rice. In rice, Chemistry and Technology, 2nd ed" Am. Assoc. Cereal Chem 1-7, 1985

      13 Pryor, W. A., "Oxy-radicals and related specied: their formation, lifetimes and reactions" 48 : 657-667, 1986

      14 Ignarro, L. J., "Oxidation of nitric oxide in aqueous solution to nitrite but not nitrite: Comparison with enzymatically formed nitric oxide form L-arginine" 90 : 8103-8107, 1993

      15 Marletta, M. A., "Nitric oxide synthase structure and mechanism" 268 : 12231-12234, 1993

      16 Farias-Eisner, R., "Nitric oxide is an important mediator for tumoricidal activity in vivo" 91 : 9407-9411, 1994

      17 Nathan, C., "Nitric oxide as a secretary product of mammalian cells" 6 : 3051-3064, 1992

      18 Guzik, T. J., "Nitric oxide and superoxide in inflammation and immune regulation" 54 : 469-487, 2003

      19 van der Veen, R. C., "Nitric oxide and T cell immunity" 1 : 1491-1500, 2001

      20 Marklund, S., "Involvement of superoxide anion radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase" 47 : 469-474, 1974

      21 Lin, H. Y., "Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1" 66 : 1821-1832, 2003

      22 Okada, T., "Effect of the defatted rice germ enriched with GABA for sleeplessness, depression, autonomic disorder by oral administration" 47 : 596-603, 2000

      23 Yun, S. J., "Cloning and characterization of a tobacco cDNA encoding calcium/ calmodulin- dependent glutamate decarboxylase" 8 : 125-129, 1998

      24 Nice D. J., "Characterization of a heat-stable antioxidant co-purified with the superoxide dismutase activity from dried peas" 52 : 393-397, 1995

      25 Kim, S. S., "Characteristics of germinated rice as a potential raw material for sikhe production" 29 : 101-106, 1997

      26 Barnick, M., "Change in phytate content and phytase during the germination of some cereals" 5 : 23-28, 1987

      27 Mody, I., "Bringing the cleft at GABA synapses in the brain" 17 : 517-525, 1994

      28 Blois, M. S., "Antioxidant determination by the use of a stable free radical" 26 : 1198-1199, 1958

      29 Torel, J., "Antioxidant activity of flavonoids and reactivity with peroxy radical" 25 : 383-385, 1986

      30 Snedden, W. A., "Activation of a recombinant petunia glutamate decarboxylase by calcium/calmodulin or by monoclonal antibody which recognizes the calmodulin binding domain" 271 : 4148-4153, 1996

      31 Nakagawa, K., "Accumulation of γ- aminobutyric acid (GABA) in the rice germ" 31 : 43-46, 1996

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