흰쥐 정소세포에서의 Cadmium 독성 작용과 Selenium 전처리의 영향 = Effects of Cadmium and Selenium Pretreatment in the Rat Testis

다국어 초록 (Multilingual Abstract)

To investigate the cadmium toxicity to testis and the effect of selenium pretreatment, male rats were subcutaneously injected with Cd and/or Se prior to Cd. In doing so, the respiration rates of mitochondria, the lysosomal activities of acid phosphatase and the cellular levels of GSH were measured. Also, the testicular ultrastructures were observed. Cd only-treated group showed that the respiration rates of mitochondria, the lysosomal activities of acid phosphatase and the level of GSH were reduced on the whole. In contrast to above group, Se-pretreated group appeared to be recovered: the respiration rate was restored more than that of control group and the enzyme activity was restored somewhat, however less than that of the control group. The level of GSH was recovered to the level of control group in Se-pretreated group. According to ultrastructural studies, Cd-treated group showed the swelling and destruction of mitochondria and the production of lipid droplets. In contrast, Se-pretreated group appeared not to be different from control group. So, all of these results would indicate that Se has a protective function against Cd toxicity in the rat testis.