세포의 체액이 증가된 환자에서의 99mTc - DTPA 를 이용한 사구체 여과율 측정의 유용성 = Utility of Measurement of GFR Using 99mTc - DTPA in Patients With Increased ECF Volume

다국어 초록 (Multilingual Abstract)

Obsectives: Of the several recent popular methods for measuring GFR using 99mTc-DTPA, it was reported that the Jackson urinary and russell two sample plasma methods are more accurate tests. But both tests have never been applied to patints with edema or ascites. In clinical practice, it is important to generate an accurate reproducible GFR in patients with changing renal function. Thus, we compared both tests with standard ioth-alamate clearance and evaluate the utility of both tests in patients with increased ECF volume. Methods: We measured Sigman's iothalamate clearance as a standard method and simultaneously measured 99mTc-DTPA clearance with Jackson urinary and Russell plasma methods in 20 patients with edema or ascites. In all patints, 24 hour creatinine clearance was mesured simultaneously, Results: 1) the range of GFR by iothalamate clerance (IC) was from 11.5 ml/min to 148 ml/min. 2) The correlation between IC and creainine clearance was described by Y=0.88X + S.30, r=0.952(p<0. 01). 3) The correlatin between IC and Jackson urinary method was described by Y =0.88X + 8,30, r=0.972 (p< 0.01), 4) The correlation between IC and Russell plasma method was described by Y=0.72X + 28,07, r=0.904 (p<0.095, 30', 180') and by Y=0.76X + 26.70, r=0.914 (p<0.05, 60', 180'). Conclusion: Jackson urinary method appears to be most reliable and precise measures of GFR in patients with increased ECF volume.