국내 갈매나무과 13종에 대한 부위별 물 추출물의 면역 증진 활성 = Immune-enhancing Activity of Water Extracts for Each Part of 13 Species (Rhamnaceae) in Korea

다국어 초록 (Multilingual Abstract)

This studied the immune-enhancing activity properties of water extracts from the leaves, branches, and fruit of 13 species (Rhamnaceae) collected during the bearing season (Berchemia berchemiifolia, B. floribunda, Hovenia dulcis, Paliurus ramosissimus, Rhamnella franguloides, Rhamnus crenata, R. davurica, R. koraiensis, R. parvifolia, R. ussuriensis, R. yoshinoi, Sageretia thea, and Ziziphus jujube). Immune-enhancing activity were studied using the nitric oxide (NO) production in RAW264.7 cells. Extracts of B. berchemiifolia, H. dulcis, R. franguloides, R. crenata, R. davurica, R. ussuriensis and S. thea showed strong immune-enhancing activity through NO production. In addition, the expression of immune enhancement-related cytokine genes (NOS, COX-2, IL-1β, IL-6 and TNF-α) were confirmed through PCR-electrophoresis.
The results of this study suggest that Rhamnaceae extracts can be used as natural antioxidants and immune enhancer.

참고문헌 (Reference)

1 Barbara J. A., "Tumour necrosis factor-alpha (TNF-α): the good, the bad and potentially very effective" 74 (74): 434-443, 1996

2 Apetoh L., "Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy" 13 (13): 1050-1059, 2017

3 Tripathi, P., "The role of nitric oxide in inflammatory reactions" 51 (51): 443-452, 2007

4 Sladkova, T., "The role of cytokines in the immune response to influenza A virus infection" 50 (50): 151-162, 2006

5 Hirayama, D., "The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis" 19 (19): 92-, 2018

6 Chang, C. S., "The distribution of the woody plants of South Korea based on herbarium(SNUA)material of the arboretum(VII)-Rhamnaceae-" 21 : 1-15, 2001

7 Medan, D., "The Families and Genera of Vascular Plants. Vol. VI" Springer 320-338, 2004

8 Choo, G. C, "Systematic studies of the family Rhamnaceae in Korea" Konkuk Univ 1992

9 Wagner, H, "Search for plant derived natural products with immunostimulatory activity(recent advances)" 62 (62): 1217-1222, 1990

10 Kim, H. N., "Sageretia thea inhibits iflammation through suppression of NF-κB and MAPK and activation of Nrf2/HO-1signaling pathways in RAW264.7 cell" 47 (47): 385-403, 2019

11 Pedersen, S.F., "SARS-CoV-2 : a storm is raging" 130 (130): 2202-2205, 2020

12 Sharma, J. N., "Role of nitric oxide in inflammatory diseases" 15 (15): 252-259, 2007

13 Xue, Q., "Regulation of iNOS on immune cells and its role in diseases" 19 (19): 3805-, 2018

14 Medzhitov, R, "Recognition of microorganisms and activation of the immune response" 449 : 819-826, 2007

15 Bohlen, H. J, "Nitric oxide and the cardiovascular system" 5 (5): 808-823, 2015

16 Radak, Z., "Nitric Oxide : Is it the cause of muscle soreness?" 26 (26): 89-94, 2012

17 Prichard, E. C, "Morphological studies in Rhamnaceae" 71 (71): 82-106, 1955

18 Mills, C. D., "Macrophages at the fork in the road to health or disease" 6 : 59-, 2015

19 Mills, C. D., "M1 and M2 macrophages : The chicken and the egg of immunity" 6 (6): 716-726, 2014

20 Sun, L., "Innate-adaptive immunity interplay and redox regulation in immune response" 37 : 101759-, 2020

21 Medzhitov, R., "Innate immune recognition : mechanisms and pathways" 173 : 89-97, 2000

22 Eo, H. J, "In vitro macrophage activation by Sageretia thea fruits through TLR2/TLR4- dependent activation of MAPK, NF-κB and PI3K/AKT signaling in RAW264.7 cells" 2 (2): 15-32, 2021

23 유선아 ; 김옥경 ; 남다은 ; 김용재 ; 백흠영 ; 전우진 ; 이정민, "Immunomodulatory effects of fermented Curcuma longa L. extracts on RAW264.7 cells" 43 (43): 216-223, 2014

24 차이왓몬마이 ; 장아영 ; 김지은 ; 이상민 ; 유상관 ; 강석범 ; 이태호 ; 박우정, "Immunomodulatory activities of body wall fatty acids extracted from Halocynthia aurantium on RAW264.7 cells" 30 (30): 1927-1936, 2020

25 Shen, C. Y., "Immune-enhancing activity of polysaccharides from Hibiscus sabdariffa Linn. via MAPK and NF-kB signaling pathways in RAW264.7 cells" 34 : 118-129, 2017

26 Geum, N. G., "Immune-enhancing activity of Hydrangea macrophylla subsp. serrata leaves through TLR4/ROSdependent activation of JNK and NF-κB in RAW264.7 cells and immunosuppressed mice" 73 : 104139-, 2020

27 Blanco-Melo D., "Imbalanced host response to SARS-CoV-2 drives development of COVID-19" 181 (181): 1036-1045, 2020

28 지선영 ; 권다혜 ; 황혜진 ; 최영현, "Evaluation of immune enhancing activity of luthione, a reduced glutathione, in RAW 264.7 macrophages" 33 (33): 397-405, 2023

29 Wauters, E., "Establishing a unified COVID-19"immunome" : Integrating coronavirus pathogenesis and host immunopathology" 11 : 1642-, 2020

30 김하나 ; 박광훈 ; 김정동 ; 박수빈 ; 어현지 ; 정진부, "Effect of the extracts from the leaves and branches of Sageretia thea on β-catenin proteasomal degradation in human colorectal and lung cancer cells" 32 (32): 153-159, 2019

31 Seillet, C., "Complexity of cytokine network regulation of innate lymphoid cells in protective immunity" 70 (70): 1-10, 2014

32 Ma, Q., "Complete chloroplast genome sequence of a major economic species, Ziziphus jujube (Rhamnaceae)" 63 (63): 117-129, 2017

33 남궁승 ; 장선아 ; 손은화 ; 박종필 ; 손은수 ; 구현정 ; 윤원종 ; 권정은 ; 정용준 ; 맹학 ; 한효상 ; 강세찬, "Comparative study of Litsea japonica leaf and fruit extract on the anti-inflammatory effects" 28 (28): 145-152, 2015

34 강연경 ; 어현지 ; 김다솜 ; 박영기 ; 송정호 ; 박광훈, "Berchemia floribunda-mediated proteasomal degradation of cyclin D1 via GSK3β-dependent threonine-286 phosphorylation in human colorectal cancer cells" 33 (33): 271-278, 2020

35 김다솜 ; 어현지 ; 강연경 ; 박광훈, "Antiinflammatory effect of Berchemia berchemiae folia leaves through inhibition of NF-κB and MAPK signaling activation in LPS-stimulated RAW264.7 cells" 34 : 31-36, 2021

36 우현심 ; 이선민 ; 허정두 ; 이민성 ; 김영수 ; 김대욱, "Anti-inflammatory activity of extracts of hovenia dulcis on lipopolysaccharides-stimulated RAW264.7 cells" 31 (31): 466-477, 2018

37 Marshall, J. S., "An introduction to immunology and immunopathology" 14 (14): 49-, 2018

38 김진현 ; 강성희 ; 마진열 ; 김성문, "A study on the extraction and efficacy of bioactive Compound from Hovenia dulcis" 21 (21): 11-15, 2006

39 Choo, G. C., "A palynotaxonomic study of the Korean Rhamnaceae" 23 (23): 175-188, 1993

40 Anggriani, N., "A mathematical COVID-19 model considering asymptomatic and symptomatic classes with waning immunity" 61 (61): 113-124, 2022