Pediatric photodermatoses = Pediatric photodermatoses

다국어 초록 (Multilingual Abstract)

Pediatric photodermatoses can be classified into 4 groups: immunologically-mediated, drug- and chemical-induced, hereditary, and photoaggrevated. An immunologically-mediated photodermatosis, polymorphous light eruption and its variant, juvenile spring eruption, is the most common photodermatosis seen in pediatric patient population. Aside from photoprotection, management includes hardening with narrowband UVB, and for young adults, a 1 week course of oral corticosteroids prior to intense sun exposure such as vacation in a sunny location. Other immunologically-mediated photodermatoses include actinic prurigo (mostly seen in American Indians), and hydroa vacciniforme (possible association with Epstein-Barr virus). Drug-induced photodermatoses are uncommon because of low prevalence of exposure to phototoxic medications in pediatric patients. Some of the porphyrias, examples of chemical-induced photodermatosis, have onset in childhood. The most common one is erythropoietic protoporphyria (potential new treatment: subcutaneous afamelanotide, an analogue of α -melanocyte stimulating hormone). Other pediatric porphyrias are congenital erythropoietic porphyria, porphyria cutanea tarda, hepatoerythropoietic porphyria, hereditary coproporphyria and variegate porphyria. Selected examples of hereditary photodermatoses will be discussed (xeroderma pigmentosum, trichothidystropy, Rothmund Thompson syndrome). Lupus erythematosus and dermatomyositis are the most common photoaggrevated dermatoses. Finally, the role of photoprotection and vitamin D in pediatric population will be discussed, with the current recommendation of daily vitamin D intake of 400 IU for 0-1 year-old, and 600 IU for 1-70 year-old.