상기도 감염 후 발생한 감각신경성 후각장애 환자에 대한 성상신경절 차단술의 치료 효과 = The Effect of Stellate Ganglion Block on the Treatment of Sensorineural Olfactory Disorder Following Upper Respiratory Tract Infection

다국어 초록 (Multilingual Abstract)

Background and Objectives Although systemic steroid is widely used, there is no established standard treatment for patients with sensorineural olfactory disorder. The aim of this study was to prospectively investigate the effect of stellate ganglion block (SGB) in patients with sensorineural olfactory disorders unresponsive to systemic steroids.
Subjects and Method Twenty patients with anosmia or hyposmia following upper respiratory tract infection (URI) that was unresponsive to systemic steroid treatments were included in this study from February 2009 through December 2009. Nine patients were treated with SGB (the treatment group) and compared with the 11 untreated patients (the control group). Except for SGB, both groups were treated the same otherwise (with topical steroids, vitamins, peripheral vasodilators) during the treatment period. We evaluated the olfactory function using Korean Version of Sniffin’ Sticks test II (KVSS II) and the subjective symptom questionnaire (SSQ).
Results The KVSS II scores improved significantly only in the treatment group, showing a significant difference between the two groups, whreas the SSQ scores were improved in both groups and did not show significant differences. KVSS II and SSQ scores showed a significant correlation.
Conclusion These results suggest that SGB may be effective in the treatment for patients with sensorineural olfactory disorder following URI unresponsiveness to systemic steroid treatments.

참고문헌 (Reference)

1 최효근, "후각역치검사, 후각인지검사와 주관적 증상간의 상관관계" 대한이비인후과학회 51 (51): 1015-1019, 2008

2 이남수, "후각 소실된 마우스에서 상경 신경절 절단이후각 세포 회복에 미치는 효과" 대한이비인후과학회 48 (48): 1462-1467, 2005

3 홍석찬, "한국인의 후각장애 원인에 대한 임상적 고찰" 대한이비인후과학회 51 (51): 717-721, 2008

4 김효열, "전신적 스테로이드가 3-Methylindole로 손상된백서 후각상피의 재생에 미치는 영향" 대한이비인후과학회 50 (50): 121-127, 2007

5 이남수, "상기도 감염 후 발생된 후각장애 환자에서 성상 신경절 차단술의 효과" 대한이비인후과학회 46 (46): 568-571, 2003

6 Fujino M, "Treatment of sudden sensorineural hearing loss with a continuous epidural block" 256 (256): S18-S21, 1999

7 Chaturvedi A, "Sympathetic blockade for the relief of chronic pain" 99 (99): 698-703, 2001

8 Yokoyama M, "Stellate ganglion block modifies the distribution of lymphocyte subsets and naturalkiller cell activity" 92 (92): 109-115, 2000

9 Murakawa K, "Stellate ganglion block for facial palsy" S532-S534, 1994

10 Min YG, "Quantitative evaluation of efficacy of systemic steroid therapy for the patients with olfactory disturbance" 41 (41): 37-41, 1998

11 Duncan HJ, "Long-term follow-up of olfactory loss secondary to head trauma and upper respiratory tract infection" 121 (121): 1183-1187, 1995

12 Seo HS, "Influences of olfactory impairment on depression, cognitive performance, and quality of life in Korean elderly" 266 (266): 1739-1745, 2009

13 Gupta MM, "Effects of stellate ganglion block on cerebral haemodynamics as assessed by transcranial Doppler ultrasonography" 95 (95): 669-673, 2005

14 Song JG, "Effects of bilateral stellate ganglion block on autonomic cardiovascular regulation" 73 (73): 1909-1913, 2009

15 Hong SC, "Development of KVSS test (Korean Version of Sniffin’ Sticks Test)" 42 (42): 855-860, 1999

16 Owen-Falkenberg A, "Continuous stellate ganglion blockade for reflex sympathetic dystrophy" 75 (75): 1041-1042, 1992

17 Treggiari MM, "Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage" 34 (34): 961-967, 2003

18 Elias M, "Cervical sympathetic and stellate ganglion blocks" 3 (3): 294-304, 2000

19 Leopold D, "A Perplexing Olfactory Loss" 126 (126): 803-, 2000