자궁내말암종에서 표피성장인자 수용체의 발현과 DNA량 분석소견 = Expression of EGFR and pattern of DNA analysis in endometrial carcinoma

다국어 초록 (Multilingual Abstract)

In endometrial carcinomas, one of the most difficult problems in clinical management has been to identify women with low stage disease who have a substantially increased risk of developing recurrence. Numerous studies to find the prognostic indicator of endometrial carcinomas were performed, but little is known about the relationship between the overexpression of epidermal growth factor receptor(EGFR) and findings of flow cytometric DNA analysis.
The immunohistochemical reactivity of antibodies against EGFR and flow cyromertic DNA analysis were examined in 19 endometrial carcinomas, and these finding were compared with histopathological findings and each other.
Thirteen of 19 cases were immunohistochemical positive for EGFR(68%). The overexpression of EGFR did not correlate with histological grade, muscle invasion, DNA ploidy, DNA index, S-phase fraction, proliferative index. The cases of high DNA index(1.89 and 1.95) were histological grade 2 and 3 with deep muscle invasion.
In this study, the overexpression of EGFR in endometrial carcinomas failed to show correlation with histopathologial findings and results of flow cytometric DNA analysis. But the high content of DNA is related to high histologic grade and deep muscle invasion, therefore it may present important prognostic information especially to patient with low clinical stage.

목차 (Table of Contents)

• I. 서론
• II. 연구재료 및 방법
• 1. 연구재료
• 2. 연구방법
• III. 결과
• 1. 임상적 소견
• 2. 조직학적 검색 소견
• 3. 조직학적 진단과 EGFR 발현여부
• 4. 조직학적 진단과 DNA 분석소견과의 관계
• 5. EGFR 발현과 DNA 분석소견과의 관계
• IV. 고찰
• V. 결론