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      간질 환아의 혈청 지질에 관한 연구 = A Study of Serum Lipids in Epileptic Children

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      https://www.riss.kr/link?id=A19590676

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      Purpose : To assess the changes of treatment of phenobarbital, carbamazepine, valproic acid and polytherapy on serum lipids in epileptic children.
      Method : We determined serum levels of total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), and triglycerides in 50 healthy children and in 80 children with epilepsy who had been receiving phenobarbital(9 patients), carbamazepine(20 patients), valproic acid(30 patients), or polytherapy (21 patients)
      Results : In the group receiving phenobarbital, mean TC, HDL-C and LDL-C levels were significantly higher than in the control group.
      In the group receiving carbamazepine, mean TC levels were significantly higher than in the control group.
      In the group receiving valproic acid, mean triglyceride and HDL-C levels were significantly lower than in the control group, but mean LDL-C/HDL-C ratio were significantly higher than in the control group.
      In the group receiving polytherapy, mean TC and LDL-C levels were significantly higher than in the control group.
      In neither group did mean TG/HDL-C ratio differs significantly from the corresponding control groups.
      Conclusion : Our results suggest long-term treatment of anticonvulsants significantly modify serum lipids in epileptic children.
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      Purpose : To assess the changes of treatment of phenobarbital, carbamazepine, valproic acid and polytherapy on serum lipids in epileptic children. Method : We determined serum levels of total cholesterol(TC), high-density lipoprotein cholesterol(HDL-...

      Purpose : To assess the changes of treatment of phenobarbital, carbamazepine, valproic acid and polytherapy on serum lipids in epileptic children.
      Method : We determined serum levels of total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), and triglycerides in 50 healthy children and in 80 children with epilepsy who had been receiving phenobarbital(9 patients), carbamazepine(20 patients), valproic acid(30 patients), or polytherapy (21 patients)
      Results : In the group receiving phenobarbital, mean TC, HDL-C and LDL-C levels were significantly higher than in the control group.
      In the group receiving carbamazepine, mean TC levels were significantly higher than in the control group.
      In the group receiving valproic acid, mean triglyceride and HDL-C levels were significantly lower than in the control group, but mean LDL-C/HDL-C ratio were significantly higher than in the control group.
      In the group receiving polytherapy, mean TC and LDL-C levels were significantly higher than in the control group.
      In neither group did mean TG/HDL-C ratio differs significantly from the corresponding control groups.
      Conclusion : Our results suggest long-term treatment of anticonvulsants significantly modify serum lipids in epileptic children.

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