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    백서에서 척수강내 투여된 Fentanyl의 ED_(50) 측정 = ED_(50) Value of Intrathecal Fentanyl in Rats

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    https://www.riss.kr/link?id=A19591379

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    The ED_50 of intrathecal fentanyl was determined using the tail clamp technique in SpragueDawley rats(N=20).
    The results are summerized as follow.
    1) The mean ED_50 value of intrathecal fentanyl was 7.4ug/kg in post-injection 5 minutes, l0ug/kg in post-injection 10 minutes, respectively.
    2) The respiratory depression and muscular rigidity were developed when the dose of intrathecal fentanyl was over 10ug/kg, recovered completely by intrathecal 0.04mg naloxone.
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    The ED_50 of intrathecal fentanyl was determined using the tail clamp technique in SpragueDawley rats(N=20). The results are summerized as follow. 1) The mean ED_50 value of intrathecal fentanyl was 7.4ug/kg in post-injection 5 minutes, l0ug/kg in p...

    The ED_50 of intrathecal fentanyl was determined using the tail clamp technique in SpragueDawley rats(N=20).
    The results are summerized as follow.
    1) The mean ED_50 value of intrathecal fentanyl was 7.4ug/kg in post-injection 5 minutes, l0ug/kg in post-injection 10 minutes, respectively.
    2) The respiratory depression and muscular rigidity were developed when the dose of intrathecal fentanyl was over 10ug/kg, recovered completely by intrathecal 0.04mg naloxone.

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