The ED_50 of intrathecal fentanyl was determined using the tail clamp technique in SpragueDawley rats(N=20).
The results are summerized as follow.
1) The mean ED_50 value of intrathecal fentanyl was 7.4ug/kg in post-injection 5 minutes, l0ug/kg in p...
The ED_50 of intrathecal fentanyl was determined using the tail clamp technique in SpragueDawley rats(N=20).
The results are summerized as follow.
1) The mean ED_50 value of intrathecal fentanyl was 7.4ug/kg in post-injection 5 minutes, l0ug/kg in post-injection 10 minutes, respectively.
2) The respiratory depression and muscular rigidity were developed when the dose of intrathecal fentanyl was over 10ug/kg, recovered completely by intrathecal 0.04mg naloxone.