오존처리에 의한 Bromate의 생성이 고환독성에 미치는 영향 = The Effect of Bromate Ion Formation by Ozonation Process and Testis Toxicity due to Bromate in rat

다국어 초록 (Multilingual Abstract)

Bromate is a chemical oxidizing agent that has been used in analytical chemistry, in four milling, in beer malting, in cheese making, as a component of home and salon permanent hair-wave kits. In this study the objective was to investigate the effects of testis toxicity due to bromate in rats. On the biological study, the body weight changes, bromate(0, 0.1, 0.2, 0.4g/L) treated group showed decreased in the body weight and testis compared to the normal group. But kidney weight was increased. Hepatic and spleen weight were not effected compared to the normal group. Lipid peroxide content in the testis was increased by bromate which was concentrated 0.4g/L for 24 weeks. Testis cytosolic enzyme system(xanthine oxidase, aldehyde oxidase) of bromate group were significantly increased in comparison with those of normal group and microsomal enzyme system were not effected. And blood testosterone concentration was significantly decreased in comparison with those of group given bromate.