Liver Transplantation in Mixed Hepatocellular Carcinoma and Cholangiocarcinoma

다국어 초록 (Multilingual Abstract)

Mixed hepatocellular carcinoma and cholangiocarcinoma (HCC-CC) are rare tumors, and the risk factors associated with them are not well understood yet. Moreover, the diagnosis of mixed HCC-CC can be complicated due to the difficulty in distinguishing mixed HCC-CC from HCC and intrahepatic CCC on radiological images. Serum tumor markers are useful when the radiological images are inconclusive. It remains unclear whether the prognosis of mixed HCC-CC differs from that of HCC. However, several studies have reported that the tumor recurrence and patient survival rates of mixed HCC-CC were similar to those of HCC after liver transplantation (LT) and liver resection. In this paper, we report that LT in patients with mixed HCC-CC achieves outcomes which are similar to those seen in LT for HCC. Therefore, the diagnosis of mixed HCC-CC should not be considered as a contraindication for LT.

참고문헌 (Reference)

1 Facciuto ME, "Tumors with intrahepatic bile duct differentiation in cirrhosis: implications on outcomes after liver transplantation" 99 : 151-157, 2015

2 Groeschl RT, "Transplantation versus resection for patients with combined hepatocellular carcinomacholangiocarcinoma" 107 : 608-612, 2013

3 Panjala C, "The diagnostic conundrum and liver transplantation outcome for combined hepatocellular-cholangiocarcinoma" 10 : 1263-1267, 2010

4 Kim KH, "Surgical treatments and prognoses of patients with combined hepatocellular carcinoma and cholangiocarcinoma" 16 : 623-629, 2009

5 Hwang S, "Super-selection of a subgroup of hepatocellular carcinoma patients at minimal risk of recurrence for liver transplantation" 15 : 971-981, 2011

6 Mazzaferro V, "Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis" 10 : 35-43, 2009

7 Jung DH, "Post-resection prognosis of combined hepatocellular carcinomacholangiocarcinoma according to the 2010 WHO classification" 41 : 1347-1357, 2017

8 Wang J, "Outcome of combined hepatocellular and cholangiocarcinoma of the liver" 2010 : 917356-, 2010

9 Sapisochin G, "Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma" 17 : 934-942, 2011

10 Vilchez V, "Long-term outcome of patients undergoing liver transplantation for mixed hepatocellular carcinoma and cholangiocarcinoma: an analysis of the UNOS database" 18 : 29-34, 2016

11 Itoh S, "Long-term outcome of living-donor liver transplantation for combined hepatocellular-cholangiocarcinoma" 35 : 2475-2476, 2015

12 Park YH, "Long-term outcome of liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma" 45 : 3038-3040, 2013

13 Chan AC, "Liver transplantation for combined hepatocellular cholangiocarcinoma" 30 : 143-146, 2007

14 Magistri P, "Liver transplantation and combined hepatocellular-cholangiocarcinoma:feasibility and outcomes" 49 : 467-470, 2017

15 Zhang H, "Intrahepatic cholangiocarcinoma:epidemiology, risk factors, diagnosis and surgical management" 379 : 198-205, 2016

16 Sapisochin G, "Intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma in patients undergoing liver transplantation: a Spanish matched cohort multicenter study" 259 : 944-952, 2014

17 Takahashi K, "Intrahepatic cholangiocarcinoma in the liver explant after liver transplantation: histological differentiation and prognosis" 21 : 208-215, 2016

18 Serra V, "Incidental intra-hepatic cholangiocarcinoma and hepatocholangiocarcinoma in liver transplantation: a single-center experience" 48 : 366-369, 2016

19 Gupta R, "Impact of incidental/misdiagnosed intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma on the outcomes of liver transplantation: an institutional case series and literature review" 47 : 908-917, 2017

20 Spagnoli FM, "Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver" 143 : 1101-1112, 1998

21 Song S, "Comparison between resection and transplantation in combined hepatocellular and cholangiocarcinoma" 45 : 3041-3046, 2013

22 Shetty AS, "Combined hepatocellular-cholangiocarcinoma: what the radiologist needs to know about biphenotypic liver carcinoma" 39 : 310-322, 2014

23 de Campos RO, "Combined hepatocellular carcinoma-cholangiocarcinoma:report of MR appearance in eleven patients" 36 : 1139-1147, 2012

24 Li R, "Combined hepatocellular carcinoma and cholangiocarcinoma (biphenotypic)tumors: clinical characteristics, imaging features of contrastenhanced ultrasound and computed tomography" 16 : 158-, 2016

25 Fowler KJ, "Combined hepatocellular and cholangiocarcinoma (biphenotypic) tumors: imaging features and diagnostic accuracy of contrast-enhanced CT and MRI" 201 : 332-339, 2013

26 Lee SD, "Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery" 13 : 594-601, 2014

27 Ijichi H, "Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma" 43 : 481-487, 2013