위점막병소에서의 Carcinoembryonic Antigen과 Secretory Component의 분포에 관한 비교연구 = A Comparative Study between Localization of Carcinoembryonic Antigen and Secretory Component in Chronic Gastritis and Stomach Cancer

다국어 초록 (Multilingual Abstract)

Recently, carcinoembryonic antigen (CEA) and secretory component (SC) are both detected immunohistochemically in the pathologic lesions of the stomach, such as metaplastic, dysplastic or anaplastic lesion. However, interrelationship between CEA and SC in their localization in the stomach is not understood well. Therefore, to understand correlation of intestinal metaplasia and carcinoma of the stomach and interrelationship between localization of CEA and SC in stomach lesions, the author collected serial 67 cases (35 cases of chronic gastritis and 32 cases of carcinorca of stomach) of formalin fixed, paraffin embedded gastric mucosa obtained by fiberscopic biopsy, performed immunoenzyme histologic reaction by Avidin-Biotin-Complex method using anti-human CEA and antihuman SC rabbit sera and analyzed their immunohistologic reactions.
Results obtained are as following;
1. Intestinal metaplasia was noted in 10 of 35 cases of chronic gastritis. And metaplastic cells in each case revealed positive reaction to both anti CEA and anti SC sera.
2. Carcinoma of stomach revealed positive reaction to anti-CEA in 71.9% (23 of 32 cases) and rate of positive reaction was higher as the differentiation of cancer cell poorer.
3. Association of metaplasia among CEA positive carcinoma of stomach was noted in 78.3% (18 of 23 cases).
4. Rate of SC positive carcinoma of stomach was 56.2% (18 of 32 cases) and there Bras no remarkable difference between degree of cancer cell differentiation and rate of SC positivity. And the cases showing SC positive carcinoma of stomach were all accompanied with metaplastic change in the lesion.
5, Carcinoma of stomach showing SC negactive reation revealed no metaplastic change in the lesions.
6. Carcinoma of stomach showing SC positive reaction were all CEA positive and also CEA negative cases were all SC negative.
Above findings show that metaplastic .and dysplastic cells in chronic gastritis are positive both CEA and SC, and SC is specific indicator of carcinoma of stomach originated from intestinal metaplasia.