The effects of base analogs on UV-light and MMS-induced unscheduled DNA synthesis and chromosome aberrations were investigated in human cells and the results obtained were as follows: BUdR and IUdR were found to be both potent sensitizers enhancing UV...
The effects of base analogs on UV-light and MMS-induced unscheduled DNA synthesis and chromosome aberrations were investigated in human cells and the results obtained were as follows: BUdR and IUdR were found to be both potent sensitizers enhancing UV-induced unscheduled DNA synthesis and chromosome aberrations. The sensitization effects of these base analogs were different in these two different repair processes. BUdR and IUdR did not seem to act as sensitizers for both unscheduled DNA synthesis and chromosome aberrations induced by MMS. These results suggest that excision repair may not be related to chromosome aberrations in human cells.