신장질환에서의 세포성면역반응 = Cell - Mediated Immunity on Renal Diseases신장질환에서의 세포성면역반응

다국어 초록 (Multilingual Abstract)

This study was undertaken to investigate whether cell-mediated immunity are affected by renal diseases. Thirty six patients with lipoid nephrosis and chronic proliferative glomerulonephritis, and 16 controlled subjects were studied by summation of delayed-cutaneous hypersensitivity response to 8 test antigens such as Tetamas, Diphtheria, Group C-streptococcus, Tuberculin, Glycerim, Candida albicans, Tricophyton mentaprophytes and protes mirabilis. The total average diameter of all positive reaction in controlled subjects was 15.34±2.03 mm. Of the 16 subjects, negatvie reaction was observed in 3 (18.8%). In patients with lipoid nephrosis, during relapsing phase the total average diameter of all positive reactions was 5.38±2.48 mm. being significantly lower than that of normal subjects. Negative reaction was observed in 9 of 10 patients (90%). The total average diameter of all positive reactions in patients with lipoid nephrosis in the remission phase was 13.09±1.64 mm showing no significant difference in total average diameters between control and remission phase group. Negative reaction was observed in 1 of 9 patients (11.1%). In chronic proliferative glomerulonephritis patients with the nephrotic syndrome, the total average diameter was 10.25±2.20 mm, showing no significant difference with control group, Negative reaction was observed in 3 of 10 patients (30%). The total average diameters of all positive reactions in patients with chronic proliferative glomrulonephritis without nephrotic syndrome was 12. 93±3.48 mm, showing non significant difference in total average diameters between control and patients group. Negative reaction was observed in 2 of 7 patients (28.56%) This study suggests lipoid nephrosis impairs cell mediated immunity, and the impairement of delayed hypersensitivity reaction seems to be related to clinical stages of nephrosis.