Colon cancer cells

목차 (Table of Contents)

• CONTENTS
• Contributors = xiii
• Preface = xvii
• 1 Colorectal Carcinoma : Key Issues / Russell Greig ; George Poste
• Text = 1
• References = 7
• Ⅰ. Normal, Preneoplastic, and Neoplastic Colonic Epithelium in Vivo and in Viko
• 2. Normal and Pathological Anatomy of the Large Intestine / Abulkalam M. Shamsuddin
• Ⅰ. Introduction = 15
• Ⅱ. Normal Large Intestine = 16
• Ⅲ. Precursors of Carcinomas = 22
• Ⅳ. Carcinoma of the Large Intestine = 26
• References = 38
• 3 Kinetics of Normal, Preneoplastic, and Neoplastic Colonic Epithelium / Eleanor E. Deschner
• Ⅰ. Introduction = 41
• Ⅱ. General Principles = 42
• Ⅲ. Normal Colon = 44
• Ⅳ. Preneoplastic Conditions = 49
• Ⅴ. Neoplasia = 52
• References = 58
• 4 Colon Carcinogenesis : Modulation of Progression / Ivan L. Cameron ; Virginia A. Ord ; Keithley E. Hunter ; David W. Heitman
• Ⅰ. Introduction 61
• Ⅱ. Multistep Model of Carcinogenesis = 64
• Ⅲ. Cell Proliferation and Colon Carcinogenesis = 66
• Ⅳ. Attempts to Modify Cell Proliferation as a Means of Modulating Progression of Colon Carcinogenesis with Special Reference to Dietary Fiber = 74
• Ⅴ. Summary and Conclusions = 81
• References = 82
• 5 In Vitro Propagation and Characterization of Normal, Preneoplastic, and Neoplastic Colonic Epithelial Cells / Mary Pat Moyer, Patrcia S. Dixon ; Alison L. Culpepper ; J. Bradley Aust
• Ⅰ. Introduction = 85
• Ⅱ. Development of Culture Methods = 87
• Ⅲ. Characterization of Cultured Cells = 103
• Ⅳ. New Avenues of Research = 119
• Ⅴ. Conclusions = 130
• References = 130
• 6 Colon Organ Culture as a Model for Carcinogenesis / Abulkalam M. Shamsuddin
• Ⅰ. Introduction = 137
• Ⅱ. Techniques = 138
• Ⅲ. Applications = 142
• Ⅳ. Carcinogenesis Studies = 143
• Ⅴ. Discussion = 148
• References = 151
• 7 Human Cell Lines in Colon Cancer Research / Lynne P. Rutzky ; Mary Pat Moyer
• Ⅰ. Introduction = 151
• Ⅱ. Origins of Cell Lines = 156
• Ⅲ. Methods and Success of Culture Initiation = 162
• Ⅳ. Growth and Morphology Characteristics = 169
• Ⅴ. Differentiation and Genetic Markers = 175
• Ⅵ. Tumorigenicity = 189
• Ⅶ. Other Phenotypic Features = 192
• Ⅷ. Conclusions = 193
• References = 195
• 8 Preclinical Evaluation of Cancer Chemotherapeutic Drugs for Treatment of Colorectal Cancer / Warner Scheithauer ; Mary Pat Moyer ; Daniel D. Von Hoff
• Ⅰ. Introduction = 201
• Ⅱ. Recent Advances in Experimental Chemotherapy of Human Colorectal Cancer = 204
• Ⅲ. Screening System Based on Use of Hunman Colorectal Cancer Cell Lines = 212
• Ⅳ. Conclusions = 218
• References = 219
• Ⅱ. Regulation of Normal and Colon Cancer Cells
• 9 Characteristics of Human Colorectal Cell Lines Established in Defined and Serum-Supplemented Media / Adi F. Gazdar ; Jae-Gahb Park ; Herbert K. Oie
• Ⅰ. Introduction = 227
• Ⅱ. Culture Methods = 228
• Ⅲ. Phenotypic Variation = 233
• Ⅳ. Antigen Expression = 244
• Ⅴ. Neuroendocrine Differentiation = 245
• Ⅵ. Other Findings = 247
• Ⅶ. Comparative Properties of SSM- and ACL-4-Derived Cell Lines = 247
• Ⅷ. Conclusions = 248
• References = 249
• 10 Growth Factors / R. Daniel Beauchamp ; Courtney M. Townsend, Jr.
• Ⅰ. Morphologic and Chemical Markers of Colonic Cell Proliferation = 253
• Ⅱ. Postoperative Colon Adaptation in Animals and Humans = 258
• Ⅲ. Luminal Factors = 260
• Ⅳ. Studies of Tropic Hormones in Vivo = 262
• Ⅴ. In Vitro Studies of Hormones and Growth Factors = 265
• Ⅵ. Studies of Carcinogenesis in Vitro = 268
• Ⅶ. Intracellular Mechanisms of Cell Proliferation = 269
• Ⅷ. Summary = 269
• References = 270
• 11 Polyamines and Colon Cancer Cells / Gordon D. Luk
• Ⅰ. Introduction = 279
• Ⅱ. Ornithine Decarboxylase and Polydmines = 280
• Ⅲ. Polyamines and Intestinal and Colonic Mucosal Growth = 281
• Ⅳ. Polyamines and Chemical Colonic Carcinogenesis = 282
• Ⅴ. Polyamines and Human Colon Cancer Cell Growth = 283
• Ⅵ. Polyamines and Human Colon Cancer Xenografts = 283
• Ⅶ. Polyamines as Markers of Colon Cancer = 284
• Ⅷ. Summary = 285
• References = 286
• 12 Current Status of Colon Cancer Cytogenetics / Avery A. Sandberg
• Ⅰ. Introduction = 289
• Ⅱ. Background = 290
• Ⅲ. Chromosome Changes in Colon Adenomas (Polyps) = 293
• Ⅳ. Chromosome Changes in Colon Cancer = 293
• Ⅴ. Colon Cancer Cell Lines = 302
• Ⅵ. Molecular Studies and Chromosome Changes = 303
• Ⅶ. Chromusome Changes and Their Role in Colon Cancer = 304
• References = 305
• Ⅲ. Metastasis
• 13 Tumorigenic and Metastatic Properties of Human Colorectal Carcinomas Transplanted into Nude Mice / Raffaella Giavazzi ; John M. Jessup ; Sen Pathak ; Kiyoshi Morikawa ; Isaiah J. Fidler
• Ⅰ. Introduction = 312
• Ⅱ. The Nude Mouse as a Recipient for Human Colorectal Neoplasms = 313
• Ⅲ. The Nude Mouse as a Model for Human Colorectal Cancer Metastasis = 317
• Ⅳ. Model for Colorectal Hepatic Metastases = 326
• Ⅴ. Clinical Correlation = 328
• Ⅵ. Conclusions = 333
• References = 334
• 14 Characterization of Colon Carcinoma Cell Metastases in Model Systems / Robert S. Bresalier ; Young S. Kim
• Ⅰ. Introduction = 342
• Ⅱ. AnimaI Tumor Models = 343
• Ⅲ. Metastasis of Human Colon Cancer Xenografts in Athymic Nude Mice = 349
• Ⅳ. Establishment of Colon Cancer Cell Lines with Enhanced Liver-Metastasizing Ability = 351
• Ⅴ. Characterization of Metastatic Colon Cancer Cell Lines Selected in an Animal Model = 359
• Ⅵ. Summary = 365
• References = 365
• 15 Patterns of Metastasis during Progression of Colorectal Cancer in Humans / Jannes L. Abbruzzeese ; Bernard Levin
• Ⅰ. Introduction = 369
• Ⅱ. Pathophysiology of Disease Spread in Patients with Colorectal Adenocarcinoma = 371
• Ⅲ. Clinical Patterns and Frequency of Metastases = 376
• Ⅳ. Predicting Eventual Development of Metastases from Evaluation of the Primary Tumor = 381
• Ⅴ. Conclusions = 389
• References = 389
• Ⅳ. Immunological Aspects of Colon Cancer
• 16 Colon Carcinoma Cell Population as Defined by Monoclonal Antibodies / Patricia Horan Hand ; Maureen O. Weeks ; David Colcher ; Ann Thor ; Noriaki Ohuchi ; Jack Greiner ; Raffaella Muraro ; David Wupiderlich ; Vincent Vilasi ; Sidney Pestka ; Philip Noguchi ; Robert Cunningham ; Jeffrey Schlom
• Ⅰ. Introduction = 398
• Ⅱ. Characterization of Novel Colon Carcinoma-Associated Antigens = 398
• Ⅲ. Monoclonal Antibodies Reactive with Colon Carcinoma-Associated Antigens = 402
• Ⅳ. Monoclonal Antibodies Reactive with Carcinoembryonic Antigen = 404
• Ⅴ. Monoclonal Antibodies Reactive with the ras Oncogene Protein Product = 405
• Ⅵ. Monoclonal Antibodies for the Delection and Monitoring of Colon Carcinoma = 409
• Ⅶ. Antigenic Heterogencity and Modulation within Human Carrinoma Cell Populations = 411
• Ⅷ. Enhancement of Tumor Antigen Expression = 414
• Ⅸ. In Situ Detection and Therapy of Colon Carcinomas Using Monoclonal Antibodies = 415
• References = 423
• 17 Carbohydrate Tumor Markers in Colon Cancer and Polyps / Elana J. Bloom ; Steven H. Itzkowitz ; Young S. Kim
• Ⅰ. Introduction = 430
• Ⅱ. Structure and Synthesis of Blood Group-Related Carbohydrate Antigens = 431
• Ⅲ. Expression of A, B, H, $$\{Le}^a$$, and $$\{Le}^b$$ Antigens = 434
• Ⅳ. Expression of Other Blood Croup-Related Carbohydratees : $$\{Le}^x$$, $$\{Le}^y$$, CA l9-9, Tag = 436
• Ⅴ. Alterations in Blood Group Antigen Expression in Colon Cancer = 437
• Ⅵ. Colon Cancer : Other Carbohydrate Tumor Markers = 445
• Ⅶ. Conclusions = 446
• References = 447
• 18 Immunobiology of Colon Cancer in Animal Models / Martin H. Coldrosen ; E. Douglas Holyoke
• Ⅰ. Introduction = 453
• Ⅱ. Methodology = 455
• Ⅲ. Orthotopic MCA-38 Tumor Cell Growth = 459
• Ⅳ. Immunological Studies = 460
• Ⅴ. In Vivo Studies on Metastasis = 465
• Ⅵ . Correlations between the Immunological Studies and the Development of Metastases = 468
• Ⅶ. Summary and conclusions = 469
• References = 473
• 19 Variable Expression of Tumor-Associated Antigens in Colon Cells : Relation to Staging, Differentiation, and Diagnosis / Carolyn Ernst Grotkowski ; Henry Sears ; Jun-Wen Shen
• Ⅰ. Introduction = 475
• Ⅱ. Study Design = 476
• Ⅲ. Antigen Heterogeneity in Normal Colonic Mucosa = 478
• Ⅳ. Antigen Heterogeneity in Colonic Carcinomas = 483
• Ⅴ. Conclusions = 492
• References = 494
• 20 Human Monoclonal Antibodies : Concepts in Development and Application to Colon Cancer / Richard P. McCabe ; Martin V. Haspel ; Nicholas Pomato ; Ronald G. Steis ; Jorge A. Carrasquillo ; Michael G. Hanna, Jr.
• Ⅰ. Introduction = 497
• Ⅱ. Application of Technology = 498
• Ⅲ. Develllprllentllt'HuillnnMunllclondIAniibodies = 500
• Ⅳ. Production of Human Monoclonal Antibodies = 506
• Ⅴ. Selection of human Monoclonal Antibodies = 507
• Ⅵ. Characterization of the Antigen = 508
• Ⅶ. In Vivo Preclinical Studies = 509
• Ⅷ. Clinical Studies = 514
• Ⅸ. Future Prospects = 515
• References = 516
• V. Conclusion
• 21 Future Prospects for Therapeutic Treatment of Colon Carcinoma / Russell G. Greig
• Ⅰ. Introduction = 521
• Ⅱ. Improveillent in Existing Strategies = 522
• Ⅲ. ImmunotherApy = 525
• Ⅳ. HorlnondITherdpy = 530
• Ⅴ. Conclusions = 531
• References = 532
• Index = 539