미숙아의 안압과 중심각막두께 = Intraocular Pressure and Central Corneal Thickness in Premature Infants

다국어 초록 (Multilingual Abstract)

Purpose: To evaluate of the range and relationship between intraocular pressure (IOP), and central corneal thickness (CCT) in
premature infants.
Methods: To investigate the correlation of IOP and CCT with gestational age and body weight, 58 premature infants 37 weeks-old
or younger were examined. Under topical anesthesia, IOP was measured with Tono-PenⓇ XL (Medtronic Solan, Jacksonville,
FL) and the CCT with pachymeter (SP-2000, TOMEYⓇ, Japan). The fundus was examined in infants with a risk of retinopathy
of prematurity (ROP).
Results: Average gestational age of the subjects was 33 weeks and 6 days and body weight was 1506±520 grams
(mean±standard deviation). Forty-five subjects had oxygen therapy, and 10 patients were found to have any one of the stages
of ROP. Average IOP was 15.14±4.64 mmHg in the right eye and 15.29±3.70 mmHg in the left eye. CCT was 594.72±74.87 μm
in the right eye and 599.78±74.17 μm in the left eye. No statistically significant correlation was found between IOP or CCT and
gestational age or body weight.
Conclusions: Gestational age and body weight did not appear to affect IOP or CCT in the gestational age between 26 and 37
weeks. The maturing eye in the neonate is known for fast development in the first year after birth. There are, however, few reports
in the literature regarding the changes in dimensions of ocular structures in the premature neonate. These normative values
may aid ophthalmologists in assessing IOP and CCT in premature infants.

국문 초록 (Abstract)

목적: 미숙아에서 안압, 중심각막두께의 범위 및 관계에 대해 알아보고자 안압, 중심각막두께와 재태기간 및 체중과의 관계를 조사하였다.
대상과 방법: 재태기간 37주 이하의 미숙아 58명 116안에 대해 점안마취 후 Tono-Pen으로 안압을 측정하고 초음파각막두께측정기로
중심각막두께를 측정하였다. 미숙아망막병증의 위험인자가 있는 환아에 대해서는 미숙아망막병증 여부에 대한 안저검사를 시행하였다.
결과: 평균 재태기간은 33주 6일이었고 체중은 1506±520 g이었다. 안압은 평균 우안 15.14±4.64 mmHg, 좌안 15.29±3.70 mmHg였고
중심각막두께는 평균 우안 594.72±74.87 μm, 좌안 599.78±74.17 μm였다. 재태기간이나 체중에 따른 안압 및 중심각막두께의 차이는
없었으며 안압과 중심각막두께의 유의한 관련성은 없었다.
결론: 미숙아에서 재태기간, 체중은 안압과 중심각막두께에 영향을 주지 않는 것으로 나타났으며 안압과 중심각막두께사이에도 유의한
관련이 없었다. 미숙아에 있어서 중심각막두께, 안압의 관계 등에 대한 보고가 국내에서는 아직 없는 상태로 향후 미숙아의 안과적 질환
연구의 기준치로서 도움이 될 것으로 생각한다.

참고문헌 (Reference)

1 Duane TD, "Valsalva hemorrhagic retinopathy" 70 : 298-313, 1972

2 Magora F, "The influence of general anesthetic agents on intraocular pressure in man" 66 : 806-811, 1961

3 Kim WJ, "The change of axial length according to age in the eyeball of premature infants by ultrasonic biometry" 34 : 667-671, 1993

4 Radtke N, "Intraocular pressure measurement in the newborn" 78 : 501-504, 1974

5 Kornbleuth W, "Intraocular pressure in the newborn measured under general anesthesia" 67 : 750-752, 1962

6 Johnson M, "Increased corneal thickness simulating elevated intraocular pressure" 96 : 664-665, 1978

7 Ha DW, "IOP & Corneal diameter in premature infants" 41 : 1953-1959, 2000

8 Zheng Y, "Heritability of central corneal thickness in Chinese: The Guangzhou Twin Eye Study" 49 : 4303-4307, 2008

9 Salz JJ, "Evaluation and comparison of sources of variability in the measurement of corneal thickness with ultrasonic and optical pachymeters" 14 : 750-754, 1983

10 Tucker SM, "Corneal diameter, axial length, and intraocular pressure in premature infants" 99 : 1296-1300, 1992

11 Autzen T, "Central corneal thickness in premature babies" 69 : 251-252, 1991

12 Ehlers N, "Central corneal thickness in newborns and children" 54 : 285-290, 1976

13 Autzen T, "Central corneal thickness in full-term newborns" 67 : 719-720, 1989

14 Muir KW, "Central corneal thickness and its relationship to intraocular pressure in children" 111 : 2220-2223, 2004

15 Kirwan C, "Central corneal thickness and corneal diameter in premature infants" 83 : 751-753, 2005

16 Remón L, "Central and peripheral corneal thickness in full-term newborns by ultrasonic pachymetry" 33 : 3080-3083, 1992

17 Haider KM, "Age and racial variation in central corneal thickness of preschool and school-aged children" 45 : 227-233, 2008