규칙적인 운동이 성인 백서 해마 치상회에서 신경세포의 Dendritic Lengths 및 Synapsin 1 수준에 미치는 영향 = Effects of Regular Exercise on Neuronal Dendrite Length and SynapsinⅠ Levels in the Hippocampal Dentate Gyrus of Adult Rats

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate effects of regular exercise (swimming exercise, treadmill exercise) on neuronal dendrite length and synapsin 1 levels in the hippocampal dentate gyrus of adult rats. Subject were composed of 24 adult male Sprague-dawley (490-510g, 24weeks old) rats. Subjects were divided into three group (TEG, n=8). Swimming and treadmill exercise was performed 5 times per week and 50 minutes per day for 8weeks. Immunohistochemistry for neuronal dendrite length and Western blot were performed to determine expression synapsin 1 protein. The result of this study are as follow, DCX(doublecortin)-labeled cell expression were significantly increased exercise group(swimming, treadmill exercise). DCX dendritic length were significantly development in exercise group(swimming, treadmill exercise). Synapsin 1 protein were significantly increased in exercise group(swimming, treadmill exercise). In conclusion, these results suggest that regular exercise in the adult rats enhance immature neuron development and synaptic plasticity.