Glutamate에 의한 산화적 스트레스로부터 신경세포를 보호하는제비꽃 추출물의 영향 = Protective Effect of Neuronal Cell on Glutamate-induced OxidativeStress from Viola mandshurica Extracts

다국어 초록 (Multilingual Abstract)

The present study describes glutamate which is known as excitatory neurotransmitter is related
with oxidative damages and the Viola mandshurica extracts. Showed protective effects against
glutamate-induced cytotoxicity. The protective effect of antioxidant on the glutamate treated N18-
RE-105 cells was determined by a MTT reduction assay. The neuroprotective effect of methanol,
ethanol, and acetone extracts from V. mandshurica against glutamate-induced cytotoxicity was
assessed by the results of an MTT reduction assay. Among the three extracts, the acetone extract
showed the highest protective effect by the results of an lactate dehydrogenase release assay. Therefore,
these results suggest that V. mandshurica extracts could be a new potential candidate against
glutamate-induced oxidative stress.

다국어 초록 (Multilingual Abstract)

The present study describes glutamate which is known as excitatory neurotransmitter is related
with oxidative damages and the Viola mandshurica extracts. Showed protective effects against
glutamate-induced cytotoxicity. The protective effect of antioxidant on the glutamate treated N18-
RE-105 cells was determined by a MTT reduction assay. The neuroprotective effect of methanol,
ethanol, and acetone extracts from V. mandshurica against glutamate-induced cytotoxicity was
assessed by the results of an MTT reduction assay. Among the three extracts, the acetone extract
showed the highest protective effect by the results of an lactate dehydrogenase release assay. Therefore,
these results suggest that V. mandshurica extracts could be a new potential candidate against
glutamate-induced oxidative stress.

참고문헌 (Reference)

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