COVID-19 유행 시기의 조현병 환자 지원 = Supporting Patients With Schizophrenia in the Era of COVID-19

다국어 초록 (Multilingual Abstract)

The coronavirus disease 2019 (COVID-19) pandemic has drastically impacted our society and health care system. People with schizophrenia are more vulnerable to this burden of illness and related societal changes. In addition, they are more susceptible to the transmission of COVID-19 and have a significantly higher mortality rate compared to the general population. In a recent study, vaccinated patients with schizophrenia showed a greatly decreased mortality level similar to that of the general population. However, patients with schizophrenia were less likely to be vaccinated. Mental health professionals should provide them with appropriate information on prevention strategies against COVID-19 and vaccination. Long-lasting social distancing and social disconnection can make people with schizophrenia more vulnerable to loneliness and depression. Furthermore, patients with schizophrenia may face challenges continuing psychiatric treatment due to the COVID-19 pandemic. Social support and suitable mental health services using novel technologies should be developed and provided to patients with schizophrenia.

참고문헌 (Reference)

1 김성완, "조현병 환자의 인지행동치료 기반 사례관리를 위한 스마트폰 애플리케이션 개발" 대한조현병학회 19 (19): 10-16, 2016

2 김성완, "조현병 환자를 위한 정신사회적 중재" 대한신경정신의학회 57 (57): 235-243, 2018

3 Mueller AL, "Why does COVID-19 dis proportionately affect older people?" 12 : 9959-9981, 2020

4 Kim SW, "Using psychoneuroimmunity against COVID-19" 87 : 4-5, 2020

5 Ryu S, "Trends in sui cide deaths before and after the COVID-19 outbreak in Korea" Front Psychiatry 2021

6 Brown E, "The potential impact of COVID-19 on psychosis: a rapid review of contemporary epidemic and pandemic research" 222 : 79-87, 2020

7 O’Donoghue B, "The need for early intervention for psychosis to persist throughout the COVID-19 pandemic and beyond" 38 : 214-219, 2021

8 Ferraris A, "The effect of antipsychotic treatment on recurrent venous thromboembolic disease: a cohort study" 80 : 18m12656-, 2019

9 이유리, "The Relationships among Media Usage regarding COVID-19, Knowledge about Infection, and Anxiety: Structural Model Analysis" 대한의학회 35 (35): 1-11, 2020

10 Xiang YT, "The COVID-19 outbreak and psychiatric hospitals in China: managing challenges through mental health service reform" 16 : 1741-1744, 2020

11 Kozloff N, "The COVID-19 global pandemic : implications for people with schizophrenia and related disorders" 46 : 752-757, 2020

12 Ju-Wan Kim, "Telephone based Interventions for Psychological Problems in Hospital Isolated Patients with COVID-19" 대한정신약물학회 18 (18): 616-620, 2020

13 Barcella CA, "Severe mental illness is associated with increased mortality and severe course of COVID-19" 144 : 82-91, 2021

14 Sham PC, "Schizophrenia following pre-natal exposure to influenza epi demics between 1939 and 1960" 160 : 461-466, 1992

15 Barlati S, "Schizophrenia during the COVID-19pandemic" 34 : 203-210, 2021

16 Ostuzzi G, "Safety of psychotropic medications in people with COVID-19: evidence review and practical recommendations" 18 : 466-481, 2020

17 Kim SW, "Risk and protective factors of depression in the general population during the COVID-19 epidemic in Korea" 21 : 445-, 2021

18 Kopelovich SL, "Remote CBT for psychosis during the COVID-19 pandemic : challenges and opportunities" 57 : 30-34, 2021

19 Lerner AM, "Preventing the spread of SARSCoV-2 with masks and other “low-tech” interventions" 324 : 1935-1936, 2020

20 Ettman CK, "Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic" 3 : e2019686-, 2020

21 Villasante-Tezanos AG, "Pneumonia risk : approximately one-third is due to clozapine and two-thirds is due to treatment-resistant schizophrenia" 142 : 66-67, 2020

22 Sung-Wan Kim, "Physical Health Literacy and Health-related Behaviors in Patients with Psychosis" 대한정신약물학회 17 (17): 279-287, 2019

23 Shinn AK, "Perspectives on the COVID-19 pandemic and individuals with serious mental illness" 81 : 20com13412-, 2020

24 Tzur Bitan D, "Patients with schizophrenia are under-vaccinated for COVID-19 : a report from Israel" 20 : 300-301, 2021

25 Yao H, "Patients with mental health disorders in the COVID-19 epidemic" 7 : e21-, 2020

26 Kim HW, "Patients with acute myocarditis following mRNA COVID-19 vaccination" e212828-, 2021

27 Ryu S, "Network study of responses to unusualness and psychological stress during the COVID-19 outbreak in Korea" 16 : e0246894-, 2021

28 "Mindlink YouTube channel"

29 Kim SW, "Mindlink : a stigma-free youth-friendly community-based early intervention centre in Korea" 15 : 1389-1394, 2021

30 Wang AK, "Meta-analysis of cerebrospinal fluid cytokine and tryptophan catabolite alterations in psychiatric patients:comparisons between schizophrenia, bipolar disorder, and depression" 44 : 75-83, 2018

31 Vai B, "Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis" 8 : 797-812, 2021

32 National Institute for Health Research, "Long-acting injectable (LAI)antipsychotics–How to manage patients on long-acting injectable (LAI, or depot) antipsychotics during the COVID-19 pandemic"

33 Shah RR, "Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes : hypothesis with implications for personalized medicine" 43 : 400-410, 2015

34 Wang Q, "Increased risk of COVID-19 infection and mortality in people with mental disorders : analysis from electronic health records in the United States" 20 : 124-130, 2021

35 Zhand N, "Implications of the COVID-19 pandemic for patients with schizophrenia spectrum disorders: narrative review" 7 : e35-, 2021

36 Jung HR, "Factors associated with mask wearing among psychiatric inpatients during the COVID-19 pandemic" 228 : 235-236, 2021

37 Lorenz RA, "Factors associated with influenza vaccination decisions among patients with mental illness" 46 : 1-13, 2013

38 Lee Ju-Yeon, "Factors Associated With a Negative Emotional Response to News Media and Nationwide Emergency Text Alerts During the COVID-19 Outbreak in Korea" 대한신경정신의학회 18 (18): 825-830, 2021

39 Bishara D, "Emerging and experimental treat ments for COVID-19 and drug interactions with psychotropic agents" 10 : 2045125320935306-, 2020

40 Clark SR, "Elevated clozapine levels associated with infection: a sys tematic review" 192 : 50-56, 2018

41 Correll CU, "Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder" 14 : 119-136, 2015

42 Kim SW, "Effectiveness of switching to long-acting injectable aripiprazole in patients with recent-onset and chronic schizophrenia" Clin Psychopharmacol Neurosci 2021

43 Lee YR, "Differential pathways of the effects of COVID-19-related stress and fear on depression between patients with schizophrenia and the general population" NPJ Schizophr 2021

44 Kim SW, "Development and feasibility of smartphone application for cognitive behavioural case management of individuals with early psychosis" 12 : 1087-1093, 2018

45 Ryu S, "Decline in hospital visits by patients with schizophrenia early in the COVID-19 outbreak in Korea" Clin Psychopharmacol Neurosci 2021

46 Ryu Seunghyong, "Current and Future Trends in Hospital Utilization of Patients With Schizophrenia in Korea: A Time Series Analysis Using National Health Insurance Data" 대한신경정신의학회 18 (18): 795-800, 2021

47 Siskind D, "Consensus statement on the use of clozapine during the COVID-19 pandemic" 45 : 222-223, 2020

48 Kim M, "Comparison of psychosocial distress in areas with different COVID-19prevalence in Korea" 11 : 593105-, 2020

49 de Leon J, "Clozapine is strongly associated with the risk of pneumonia and inflammation" 33 : e100183-, 2020

50 McClay E, "Clozapine drug monitoring during COVID-19 for stable adult patients"

51 Kim SW, "Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness" 14 : 44-52, 2020

52 Dickerson F, "Cigarette smoking by patients with serious mental illness, 1999-2016: an increasing disparity" 69 : 147-153, 2018

53 Reilev M, "Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARSCoV-2 in Denmark: a nationwide cohort" 49 : 1468-1481, 2020

54 Seong Hoon Jeong, "Challenges in Prescribing Clozapine in the Era of COVID-19: A Review Focused on Immunological Implications" 대한정신약물학회 19 (19): 411-422, 2021

55 Perry RJ, "Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study" 398 : 1147-1156, 2021

56 Pinkham AE, "COVID-19-related psychological distress and engagement in preventative behaviors among individuals with severe mental illnesses" 7 : 7-, 2021

57 Mazereel V, "COVID-19 vac cination for people with severe mental illness: why, what, and how?" 8 : 444-450, 2021

58 Tzur Bitan D, "COVID-19 prevalence and mortality among schizophrenia patients : a large-scale retrospective cohort study" 47 : 1211-1217, 2021

59 Tzur Bitan D, "COVID-19 hos pitalisation, mortality, vaccination, and postvaccination trends among people with schizophrenia in Israel: a longitudinal cohort study" 8 : 901-908, 2021

60 Muruganandam P, "COVID-19 and severe mental illness: impact on patients and its relation with their awareness about COVID-19" 291 : 113265-, 2020

61 Poblador-Plou B, "Baseline chronic comorbidity and mortality in laboratory-confirmed COVID-19 cases: results from the PRECOVID study in Spain" 17 : 1-14, 2020

62 Nemani K, "Association of psychiatric disorders with mortality among patients with COVID-19" 78 : 380-386, 2021

63 Lee SW, "Association between mental illness and COVID-19 susceptibility and clinical outcomes in South Korea: a nationwide cohort study" 7 : 1025-1031, 2020

64 Fond G, "Association between mental health disorders and mortality among patients with COVID-19 in 7 countries: a systematic review and meta-analysis" e212274-, 2021

65 Nemani K, "Association between antipsychotic use and COVID-19 mortality among people with serious mental illness" JAMA Psychiatry 2021

66 Miles LW, "Adult vaccination rates in the mentally ill population: an outpatient improvement project" 26 : 172-180, 2020

67 Steiner J, "Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity" 260 : 509-518, 2010

68 Kim SW, "2020 Gwangju Mental Health and Welfare Commission Annual report" Gwangju Mental Health and Welfare Commission 2020

69 Taipale H, "20-year follow-up study of physical morbidity and mortal ity in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)" 19 : 61-68, 2020