1 Shelness, G. S., "Very-low-density lipoprotein assembly and secretion" 12 : 151-157, 2001
2 Yu, J., "Update on glycerol-3-phosphate acyltransferases : the roles in the development of insulin resistance" 8 : 34-, 2018
3 Khaminets, A., "Ubiquitin-dependent and independent signals in selective autophagy" 26 : 6-16, 2016
4 Alves-Bezerra, M., "Triglyceride metabolism in the liver" 8 : 1-8, 2017
5 Sharma, S., "Triggering the interferon antiviral response through an IKKrelated pathway" 300 : 1148-1151, 2003
6 Wang, Y., "Transcriptional regulation of hepatic lipogenesis" 16 : 678-689, 2015
7 Perla, F. M., "The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease" 4 : 46-, 2017
8 Hodson, L., "The regulation of hepatic fatty acid synthesis and partitioning : the effect of nutritional state" 15 : 689-700, 2019
9 Chiang, S. H., "The protein kinase IKKepsilon regulates energy balance in obese mice" 138 : 961-975, 2009
10 McGarry, J. D., "The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis" 244 : 1-14, 1997
11 Bremer, J., "The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA" 665 : 628-631, 1981
12 Younossi, Z. M., "The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe" 64 : 1577-1586, 2016
13 Chalasani, N., "The diagnosis and management of nonalcoholic fatty liver disease : practice guidance from the American Association for the Study of Liver Diseases" 67 : 328-357, 2018
14 Luo, J. L., "The anti-death machinery in IKK/NF-kappaB signaling" 25 : 541-550, 2005
15 Smith, S., "The animal fatty acid synthase : one gene, one polypeptide, seven enzymes" 8 : 1248-1259, 1994
16 Thurston, T. L., "The TBK1adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitincoated bacteria" 10 : 1215-1221, 2009
17 Amin, N. B., "Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis" 11 : eaav9701-, 2019
18 Doege, H., "Targeted deletion of FATP5 reveals multiple functions in liver metabolism : alterations in hepatic lipid homeostasis" 130 : 1245-1258, 2006
19 Matsumoto, G., "TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1phosphorylation" 24 : 4429-4442, 2015
20 Zhao, P., "TBK1 at the crossroads of inflammation and energy homeostasis in adipose" 172 : 731-743, 2018
21 Pilli, M., "TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation" 37 : 223-234, 2012
22 Huh, J. Y., "TANK-binding kinase 1 regulates the localization of Acyl-CoA synthetase ACSL1 to control hepatic fatty acid oxidation" 32 : 1012-1027, 2020
23 Zhang, C., "Structural basis of STING binding with and phosphorylation by TBK1" 567 : 394-398, 2019
24 Donnelly, K. L., "Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease" 115 : 1343-1351, 2005
25 Li, Q., "Severe liver degeneration in mice lacking the IkappaB kinase 2 gene" 284 : 321-325, 1999
26 Rudolph, D., "Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice" 14 : 854-862, 2000
27 Matsumoto, G., "Serine 403phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins" 44 : 279-289, 2011
28 Sparks, J. D., "Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia" 32 : 2104-2112, 2012
29 Zachari, M., "Selective autophagy of mitochondria on a ubiquitinendoplasmic-reticulum platform" 50 : 627-643, 2019
30 Nguyen, T. T. P., "SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice" 81 : 3820–3832.-, 2021
31 Eberle, D., "SREBP transcription factors : master regulators of lipid homeostasis" 86 : 839-848, 2004
32 Softic, S., "Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease" 61 : 1282-1293, 2016
33 Schreurs, M., "Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome" 11 : 380-388, 2010
34 Repa, J. J., "Regulation of mouse sterol regulatory element-binding protein1c gene(SREBP-1c)by oxysterol receptors, LXRalpha and LXRbeta" 14 : 2819-2830, 2000
35 Duncan, R. E., "Regulation of lipolysis in adipocytes" 27 : 79-101, 2007
36 Häcker, H., "Regulation and function of IKK and IKK-related kinases" 2006 : re13-, 2006
37 Helgason, E., "Recent insights into the complexity of Tank-binding kinase 1 signaling networks : the emerging role of cellular localization in the activation and substrate specificity of TBK1" 587 : 1230-1237, 2013
38 Rognstad, R., "Rate-limiting steps in metabolic pathways" 254 : 1875-1878, 1979
39 Browning, J. D., "Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity" 40 : 1387-1395, 2004
40 Wild, P., "Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth" 333 : 228-233, 2011
41 Beraza, N., "Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis" 57 : 655-663, 2008
42 Seessle, J., "Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis" 1851 : 549-565, 2015
43 Tontonoz, P., "PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL" 93 : 241-252, 1998
44 Owen, M. R., "Overt and latent activities of diacylglycerol acytransferase in rat liver microsomes : possible roles in very-lowdensity lipoprotein triacylglycerol secretion" 323 : 17-21, 1997
45 Li, L. O., "Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes" 281 : 37246-37255, 2006
46 Bagnato, C., "Overexpression of diacylglycerol acyltransferase-1reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts" 278 : 52203-52211, 2003
47 Krammer, J., "Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells" 8 : 599-614, 2011
48 Weisberg, S. P., "Obesity is associated with macrophage accumulation in adipose tissue" 112 : 1796-1808, 2003
49 Lumeng, C. N., "Obesity induces a phenotypic switch in adipose tissue macrophage polarization" 117 : 175-184, 2007
50 Li, X., "Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100" 38 : 1277-1288, 1997
51 Fabbrini, E., "Obesity and nonalcoholic fatty liver disease : biochemical, metabolic, and clinical implications" 51 : 679-689, 2010
52 Kim, J. B., "Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1" 101 : 1-9, 1998
53 Gruben, N., "Nonalcoholic fatty liver disease: a main driver of insulin resistance or a dangerous liaison?" 1842 : 2329-2343, 2014
54 Koo, S. H., "Nonalcoholic fatty liver disease : molecular mechanisms for the hepatic steatosis" 19 : 210-215, 2013
55 Sun, S. C., "Non-canonical NF-kappaB signaling pathway" 21 : 71-85, 2011
56 Sheng, L., "NF-kappaB-inducing kinase(NIK)promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action" 18 : 943-949, 2012
57 Luedde, T., "NF-kappaB in the liver–linking injury, fibrosis and hepatocellular carcinoma" 8 : 108-118, 2011
58 Tojima, Y., "NAK is an IkappaB kinase-activating kinase" 404 : 778-782, 2000
59 Abu-Elheiga, L., "Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal" 102 : 12011-12016, 2005
60 Shen, H., "Mouse hepatocyte overexpression of NF-kappaB-inducing kinase(NIK)triggers fatal macrophage-dependent liver injury and fibrosis" 60 : 2065-2076, 2014
61 Ipsen, D. H., "Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease" 75 : 3313-3327, 2018
62 Ma, X., "Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation" 109 : 9378-9383, 2012
63 Estes, C., "Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease" 67 : 123-133, 2018
64 Pickles, S., "Mitophagy and quality control mechanisms in mitochondrial maintenance" 28 : R170-R185, 2018
65 Lou, G., "Mitophagy and neuroprotection" 26 : 8-20, 2020
66 조동형, "Mitophagy and Innate Immunity in Infection" 한국분자세포생물학회 43 (43): 10-22, 2020
67 Hammond, L. E., "Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs" 280 : 25629-25636, 2005
68 Lee, K., "Mitochondrial carnitine palmitoyltransferase 1a(CPT1a)is part of an outer membrane fatty acid transfer complex" 286 : 25655-25662, 2011
69 Adeva-Andany, M. M., "Mitochondrial beta-oxidation of saturated fatty acids in humans" 46 : 73-90, 2019
70 Wallace, D. C., "Mitochondria and cancer" 12 : 685-698, 2012
71 Miranda, P. J., "Metabolic syndrome : definition, pathophysiology, and mechanisms" 149 : 33-45, 2005
72 Abumrad, N., "Membrane proteins implicated in longchain fatty acid uptake by mammalian cells : CD36, FATP and FABPm" 1441 : 4-13, 1999
73 Coleman, R. A., "Mammalian triacylglycerol metabolism : synthesis, lipolysis, and signaling" 111 : 6359-6386, 2011
74 Soupene, E., "Mammalian long-chain acyl-CoA synthetases" 233 : 507-521, 2008
75 Young, P. A., "Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways" 293 : 16724-16740, 2018
76 Cai, D., "Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB" 11 : 183-190, 2005
77 Li, L. O., "Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition" 284 : 27816-27826, 2009
78 Mao, J., "Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis" 103 : 8552-8557, 2006
79 Higuchi, N., "Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease" 38 : 1122-1129, 2008
80 Liu, Y., "Liver NF-kappaB-inducing kinase promotes liver steatosis and glucose counterregulation in male mice with obesity" 158 : 1207-1216, 2017
81 신동욱, "Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders" 한국분자세포생물학회 43 (43): 686-693, 2020
82 Carotti, S., "Lipophagy impairment is associated with disease progression in NAFLD" 11 : 850-, 2020
83 Avramoglu, R. K., "Lipid and lipoprotein dysregulation in insulin resistant states" 368 : 1-19, 2006
84 Coleman, R. A., "It takes a village : channeling fatty acid metabolism and triacylglycerol formation via protein interactomes" 60 : 490-497, 2019
85 Mowers, J., "Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKepsilon and TBK1" 2 : e01119-, 2013
86 Shoelson, S. E., "Inflammation and insulin resistance" 116 : 1793-1801, 2006
87 Choi, S. H., "Increased very low density lipoprotein(VLDL)secretion, hepatic steatosis, and insulin resistance" 22 : 353-363, 2011
88 Chen, H. C., "Increased insulin and leptin sensitivity in mice lacking acyl CoA : diacylglycerol acyltransferase 1" 109 : 1049-1055, 2002
89 Lumeng, C. N., "Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity" 56 : 16-23, 2007
90 Trigatti, B. L., "Identification of caveolin-1 as a fatty acid binding protein" 255 : 34-39, 1999
91 Nagle, C. A., "Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/-mice" 49 : 823-831, 2008
92 Seth, R. B., "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3" 122 : 669-682, 2005
93 Fitzgerald, K. A., "IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway" 4 : 491-496, 2003
94 Maeda, S., "IKKbeta is required for prevention of apoptosis mediated by cellbound but not by circulating TNFalpha" 19 : 725-737, 2003
95 Maeda, S., "IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis" 121 : 977-990, 2005
96 Kishore, N., "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2 : comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2" 277 : 13840-13847, 2002
97 Rothwarf, D. M., "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex" 395 : 297-300, 1998
98 Arkan, M. C., "IKK-beta links inflammation to obesity-induced insulin resistance" 11 : 191-198, 2005
99 Lin, J., "Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP" 120 : 261-273, 2005
100 Wilson, C. G., "Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice" 157 : 570-585, 2016
101 van Diepen, J. A., "Hepatocyte-specific IKK-beta activation enhances VLDLtriglyceride production in APOE*3-Leiden mice" 52 : 942-950, 2011
102 Beraza, N., "Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury" 132 : 2504-2517, 2007
103 Gluchowski, N. L., "Hepatocyte deletion of triglyceride-synthesis enzyme acyl CoA : diacylglycerol acyltransferase 2 reduces steatosis without increasing inflammation or fibrosis in mice" 70 : 1972-1985, 2019
104 Ferre, P., "Hepatic steatosis : a role for de novo lipogenesis and the transcription factor SREBP-1c" 12 : 83-92, 2010
105 Mashek, D. G., "Hepatic fatty acid trafficking : multiple forks in the road" 4 : 697-710, 2013
106 Sunami, Y., "Hepatic activation of IKK/NFkappaB signaling induces liver fibrosis via macrophage-mediated chronic inflammation" 56 : 1117-1128, 2012
107 Wunderlich, F. T., "Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis" 105 : 1297-1302, 2008
108 Wendel, A. A., "Glycerol-3-phosphate acyltransferases : rate limiting enzymes of triacylglycerol biosynthesis" 1791 : 501-506, 2009
109 Younossi, Z. M., "Global epidemiology of nonalcoholic fatty liver diseaseMeta-analytic assessment of prevalence, incidence, and outcomes" 64 : 73-84, 2016
110 Goncalves, A., "Functional dissection of the TBK1 molecular network" 6 : e23971-, 2011
111 Brandt, J. M., "Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha" 273 : 23786-23792, 1998
112 Stahl, A., "Fatty acid transport proteins : a current view of a growing family" 12 : 266-273, 2001
113 Chirala, S. S., "Fatty acid synthesis is essential in embryonic development : fatty acid synthase null mutants and most of the heterozygotes die in utero" 100 : 6358-6363, 2003
114 Syed-Abdul, M. M., "Fatty acid synthase inhibitor TVB-2640 reduces hepatic de novo lipogenesis in males with metabolic abnormalities" 72 : 103-118, 2020
115 Kim, J. H., "Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones" 276 : 24667-24673, 2001
116 Watkins, P. A., "Evidence for 26 distinct acylcoenzyme A synthetase genes in the human genome" 48 : 2736-2750, 2007
117 Tanaka, M., "Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice" 10 : 421-429, 1999
118 Saggerson, E. D., "Effects of fasting, adrenalectomy and streptozotocin-diabetes on sensitivity of hepatic carnitine acyltransferase to malonyl CoA" 129 : 225-228, 1981
119 Perry, A. K., "Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection" 199 : 1651-1658, 2004
120 Iizuka, K., "Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis" 101 : 7281-7286, 2004
121 Bonnard, M., "Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription" 19 : 4976-4985, 2000
122 Sanders, F. W., "De novo lipogenesis in the liver in health and disease : more than just a shunting yard for glucose" 91 : 452-468, 2016
123 허진영, "Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity" 한국분자세포생물학회 37 (37): 365-371, 2014
124 Mascaro, C., "Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor" 273 : 8560-8563, 1998
125 Diraison, F., "Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease" 29 : 478-485, 2003
126 Abu-Elheiga, L., "Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2" 291 : 2613-2616, 2001
127 Yamaoka, S., "Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation" 93 : 1231-1240, 1998
128 Milger, K., "Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4" 119 : 4678-4688, 2006
129 Kumashiro, N., "Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease" 108 : 16381-16385, 2011
130 Longo, N., "Carnitine transport and fatty acid oxidation" 1863 : 2422-2435, 2016
131 Dentin, R., "Carbohydrate responsive element binding protein(ChREBP)and sterol regulatory element binding protein-1c(SREBP-1c) : two key regulators of glucose metabolism and lipid synthesis in liver" 87 : 81-86, 2005
132 Singh, R., "Autophagy regulates lipid metabolism" 458 : 1131-1135, 2009
133 Chun-Seok Cho, "Autophagy Dysregulation and Obesity-Associated Pathologies" 한국분자세포생물학회 41 (41): 3-10, 2018
134 Saitoh, T., "Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response" 106 : 20842-20846, 2009
135 Vergnes, L., "Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity" 47 : 745-754, 2006
136 Choe, S. S., "Adipose tissue remodeling : its role in energy metabolism and metabolic disorders" 7 : 30-, 2016
137 Digel, M., "Acyl-CoA synthetases : fatty acid uptake and metabolic channeling" 326 : 23-28, 2009
138 Grevengoed, T. J., "Acyl-CoA metabolism and partitioning" 34 : 1-30, 2014
139 Despres, J. P., "Abdominal obesity and metabolic syndrome" 444 : 881-887, 2006
140 Seabright, A. P., "AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner" 34 : 6284-6301, 2020
141 Muoio, D. M., "AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle : evidence that sn-glycerol-3-phosphate acyltransferase is a novel target" 338 : 783-791, 1999
142 Buque, X., "A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats" 51 : 500-513, 2010
143 Yamashita, H., "A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver" 98 : 9116-9121, 2001
144 Chakravarthy, M. V., ""New"hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis" 1 : 309-322, 2005