Multicentric Breast Cancer of the Axillary and Pectoral Breasts: A Case Report and Literature Review

다국어 초록 (Multilingual Abstract)

Multicentric cancer of the pectoral and ectopic breasts is extremely rare, and diagnosing this malignancy remains challenging because axillary breast cancer is easily misdiagnosed as lymph node metastasis. Moreover, there are no established treatment guidelines for this disease. We present our experience with a multicentric breast cancer patient who showed different responses to neoadjuvant chemotherapy (NAC) and underwent surgical treatments that differed from those in previous studies. In our case, the preoperative imaging of both lesions and subsequent core needle biopsy of each lesion were crucial, as these procedures confirm the diagnosis and help decide the chemotherapy regimen based on the subtype. After NAC, the patient underwent right breast-conserving surgery, sentinel lymph node biopsy (SLNB), and excision of accessory breast tissue in the right axilla. SLNB should be the initial step in staging multicentric breast cancer, unless imaging scan shows evidence of lymph node metastasis.

참고문헌 (Reference)

1 Moore KL, "The Developing Human: Clinically Oriented Embryology" Saunders 2018

2 Lim HS, "Sonographic findings of accessory breast tissue in axilla and related diseases" 36 : 1469-1478, 2017

3 Togawa K, "Risk factors for self-reported arm lymphedema among female breast cancer survivors : a prospective cohort study" 16 : 414-, 2014

4 Famá F, "Prevalence of ectopic breast tissue and tumor : a 20-year single center experience" 16 : e107-e112, 2016

5 Shinseki K, "One case of accessory breast cancer complicated by contralateral breast cancer" 47 : 1703-1705, 2020

6 Purushotham AD, "Morbidity after sentinel lymph node biopsy in primary breast cancer : results from a randomized controlled trial" 23 : 4312-4321, 2005

7 Munrós J, "Management of breast carcinoma in ectopic axillary breast tissue" 95 : 232-233, 2017

8 오승원 ; 임효순 ; 이지신 ; 문성민 ; 박민호, "Invasive Micropapillary Carcinoma in Axillary Ectopic Breast and Synchronous Ductal Carcinoma In Situ in the Contralateral Breast" 한국유방암학회 20 (20): 314-318, 2017

9 Marshall MB, "Ectopic breast cancer : case report and literature review" 3 : 295-304, 1994

10 Cardoso F, "Early breast cancer:ESMO clinical practice guidelines for diagnosis, treatment and follow-up" 30 : 1674-, 2019

11 Addae JK, "Case of second primary breast cancer in ectopic breast tissue and review of the literature" 14 : e241361-, 2021

12 Zhang J, "Axillary accessory breast cancer with persistent leftsuperior vena cava : a case report and treatment controversy" 73 : 71-74, 2020

13 Visconti G, "Approach and management of primary ectopic breast carcinoma in the axilla : where are we? A comprehensive historical literature review" 64 : e1-e11, 2011

14 Hao JY, "Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas : a report of two cases and literature review" 9 : 197-201, 2012

15 Intra M, "A rare association of synchronous intraductal carcinoma of the breast and invasive carcinoma of ectopic breast tissue of the vulva: case report and literature review" 16 (16): 428-433, 2006

16 Nihon-Yanagi Y, "A case of ectopic breast cancer with a literature review" 20 : 35-42, 2011