RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      KCI등재 SCIE SCOPUS

      Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model

      한글로보기

      https://www.riss.kr/link?id=A104770037

      • 0

        상세조회
      • 0

        다운로드
      서지정보 열기
      • 내보내기
      • 내책장담기
      • 공유하기
      • 오류접수

      부가정보

      다국어 초록 (Multilingual Abstract)

      Obesity has increased continuously in western countries during the last several decades and recently become a problem in developing countries. Currently, anti-obesity drugs originating from natural products are being investigated for their potential to overcome adverse effects associated with chemical drugs. Artemisinic acid, which was isolated from the well-known anti-malaria herb Artemisia annua (AA) L., was recently shown to possess anti-adipogenic effects in vitro. However, the anti-adipogenic effects of AA in animal models have not yet been investigated. Therefore, we conducted daily oral administration with AA water extract in a diet-induced obesity animal model and treated 3T3-L1 cells with AA to confirm the anti-adipogenic effects in the related protein expressions. We then evaluated the physiology, adipose tissue histology and mRNA expressions of many related genes. Inhibition of adipogenesis by the AA water extract was observed in vitro. In the animal model, weight gain was significantly lower in the AA treated group, but there were no changes in food intake volume or calories. Reductions in lipid droplet size and mRNA expression associated with adipogenesis were also observed in animal epididymal fat. This study is the first to report that AA has an anti-obese effects in vivo.
      번역하기

      Obesity has increased continuously in western countries during the last several decades and recently become a problem in developing countries. Currently, anti-obesity drugs originating from natural products are being investigated for their potential t...

      Obesity has increased continuously in western countries during the last several decades and recently become a problem in developing countries. Currently, anti-obesity drugs originating from natural products are being investigated for their potential to overcome adverse effects associated with chemical drugs. Artemisinic acid, which was isolated from the well-known anti-malaria herb Artemisia annua (AA) L., was recently shown to possess anti-adipogenic effects in vitro. However, the anti-adipogenic effects of AA in animal models have not yet been investigated. Therefore, we conducted daily oral administration with AA water extract in a diet-induced obesity animal model and treated 3T3-L1 cells with AA to confirm the anti-adipogenic effects in the related protein expressions. We then evaluated the physiology, adipose tissue histology and mRNA expressions of many related genes. Inhibition of adipogenesis by the AA water extract was observed in vitro. In the animal model, weight gain was significantly lower in the AA treated group, but there were no changes in food intake volume or calories. Reductions in lipid droplet size and mRNA expression associated with adipogenesis were also observed in animal epididymal fat. This study is the first to report that AA has an anti-obese effects in vivo.

      더보기

      참고문헌 (Reference)

      1 Bag S, "fabp4 is central to eight obesity associated genes: a functional gene network-based polymorphic study" 364 : 344-354, 2015

      2 Lai CS, "Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPARγ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways" 60 : 1094-1101, 2012

      3 Kim SK, "Visceral fat th ickness measured by ultrasonography can estimate not only visceral obesity but also risks of cardiovascular and metabolic diseases" 79 : 593-599, 2004

      4 Hsueh WA, "The central role of fat and effect of peroxisome proliferator-activated receptor-γ on progression of insulin resistance and cardiovascular disease" 92 (92): 3J-9J, 2003

      5 Knudsmark Jessing K, "Potential ecological roles of artemisinin produced by Artemisia annua L" 40 : 100-117, 2014

      6 Lee MR, "Plants against malaria, part 2: Artemisia annua (Qinghaosu or the sweet wormwood)" 32 : 300-305, 2002

      7 Frühbeck G, "Overview of adipose tissue and its role in obesity and metabolic disorders" 456 : 1-22, 2008

      8 Ballinger A, "Orlistat in the treatment of obesity" 1 : 841-847, 2000

      9 Taupin V, "Modulation of tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-8, and granulocyte/macrophage colony-stimulating factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand, triakontatetraneuropeptide: evidence for a role of prostaglandins" 43 : 64-69, 1993

      10 Coskun H, "Mathematical modeling of preadipocyte fate determination" 265 : 87-94, 2010

      1 Bag S, "fabp4 is central to eight obesity associated genes: a functional gene network-based polymorphic study" 364 : 344-354, 2015

      2 Lai CS, "Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPARγ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways" 60 : 1094-1101, 2012

      3 Kim SK, "Visceral fat th ickness measured by ultrasonography can estimate not only visceral obesity but also risks of cardiovascular and metabolic diseases" 79 : 593-599, 2004

      4 Hsueh WA, "The central role of fat and effect of peroxisome proliferator-activated receptor-γ on progression of insulin resistance and cardiovascular disease" 92 (92): 3J-9J, 2003

      5 Knudsmark Jessing K, "Potential ecological roles of artemisinin produced by Artemisia annua L" 40 : 100-117, 2014

      6 Lee MR, "Plants against malaria, part 2: Artemisia annua (Qinghaosu or the sweet wormwood)" 32 : 300-305, 2002

      7 Frühbeck G, "Overview of adipose tissue and its role in obesity and metabolic disorders" 456 : 1-22, 2008

      8 Ballinger A, "Orlistat in the treatment of obesity" 1 : 841-847, 2000

      9 Taupin V, "Modulation of tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-8, and granulocyte/macrophage colony-stimulating factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand, triakontatetraneuropeptide: evidence for a role of prostaglandins" 43 : 64-69, 1993

      10 Coskun H, "Mathematical modeling of preadipocyte fate determination" 265 : 87-94, 2010

      11 Bai Y, "Macrophage recruitment in obese adipose tissue" 16 : 127-136, 2015

      12 Qi S, "Lotus seed epicarp extract as potential antioxidant and anti-obesity additive in Chinese Cantonese sausage" 93 : 257-262, 2013

      13 Siebenhofer A, "Long-term effects of weight-reducing drugs in hypertensive patients" 3 : CD007654-, 2013

      14 Jackson HC, "Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat" 121 : 1613-1618, 1997

      15 Exley MA, "Interplay between the immune system and adipose tissue in obesity" 223 : R41-R48, 2014

      16 Choi S, "Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions" 928 : 30-39, 2002

      17 Rethorst CD, "Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES)" 75 : e1428-e1432, 2014

      18 Bello NT, "High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor" 2013 : 457047-, 2013

      19 McDonald MK, "Functional significance of macrophage-derived exosomes in inflammation and pain" 155 : 1527-1539, 2014

      20 Torkildsen Ø, "Fat-soluble vitamins as disease modulators in multiple sclerosis" s196 : 16-23, 2013

      21 Tiele OW, "Fat, hypertension and arteriosclerosis in the experimental animal" 45 : 512-, 1974

      22 Garin-Shkolnik T, "FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues" 63 : 900-911, 2014

      23 Choi S, "Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression" 1087 : 83-86, 2006

      24 Wu B, "Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer" 27 : 101-108, 2012

      25 Yoshioka S, "Dietary fat-induced increase in blood pressure and insulin resistance in rats" 18 : 1857-1864, 2000

      26 Scott B, "Dietary fat influences electric membrane properties of neurons in cell culture" 9 : 105-113, 1989

      27 Xing Z, "Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation" 10 : 148-153, 1994

      28 Aral LA, "Comparison of hippocampal interleukin-6 immunoreactivity after exhaustive exercise in both exercise-trained and untrained rats" 44 : 560-568, 2014

      29 Vereyken EJF, "Chronic interleukin-6 alters the level of synaptic proteins in hippocampus in culture and in vivo" 25 : 3605-3616, 2007

      30 Comerma-Steffensen S, "Cardiovascular effects of current and future anti-obesity drugs" 12 : 493-504, 2014

      31 Yang HN, "C/EBP-α and C/EBP-β-mediated adipogenesis of human mesenchymal stem cells (hMSCs)using PLGA nanoparticles complexed with poly (ethyleneimmine)" 32 : 5924-5933, 2011

      32 Peterson HR, "Body fat and the activity of the autonomic nervous system" 318 : 1077-1083, 1988

      33 Lee J, "Artemisinic acid is a regulator of adipocyte differentiation and C/EBP δ expression" 113 : 2488-2499, 2012

      34 RITAM Artemisia annua Task Force, "Artemisia annua as a herbal tea for malaria" 4 : 121-123, 2006

      35 Lee H, "Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway" 23 : 1615-1623, 2009

      36 Tan S, "Antiobese effects of capsaicin-chitosan microsphere (CCMS) in obese rats induced by high fat diet" 62 : 1866-1874, 2014

      37 Fantuzzi G, "Adipose tissue, adipokines, and inflammation" 115 : 911-919, 2005

      38 Pikkel YY, "Acute bilateral glaucoma and panuveitis as a side effect of topiramate for weight loss treatment" 2014 : bcr2014203-, 2014

      39 Fu M, "A nuclear receptor atlas: 3T3-L1adipogenesis" 19 : 2437-2450, 2005

      40 Jeong HW, "A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor α and γ" 60 : 496-506, 2011

      더보기

      분석정보

      View

      상세정보조회

      0

      Usage

      원문다운로드

      0

      대출신청

      0

      복사신청

      0

      EDDS신청

      0

      동일 주제 내 활용도 TOP

      더보기

      주제

      연도별 연구동향

      연도별 활용동향

      연관논문

      연구자 네트워크맵

      공동연구자 (7)

      유사연구자 (20) 활용도상위20명

      인용정보 인용지수 설명보기

      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2005-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2003-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
      더보기

      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.08 0.11 0.76
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.61 0.51 0.245 0.05
      더보기

      이 자료와 함께 이용한 RISS 자료

      나만을 위한 추천자료

      해외이동버튼