To treat cancer more effectively, combination therapy has been studied with photodynamic therapy(PDT). We designed nature-inspired polymer nanoparticles which have biocompatibility and photothermal effect under NIR condition. These nanoparticles coate...
To treat cancer more effectively, combination therapy has been studied with photodynamic therapy(PDT). We designed nature-inspired polymer nanoparticles which have biocompatibility and photothermal effect under NIR condition. These nanoparticles coated with glycosaminoglycan that is also biocompatible natural polymer and able to target cancerous cells. Photosensitizer(PS), a powerful reactive oxygen species (ROS) generator, is conjugated with glycosaminoglycan so that photodynamic effect can be controllable. Cancer specific therapy is an important issue in PDT, because of unwanted side-effects. Our nanoparticles(NGPs) have high water solubility, cancer selective internalization, controlled toxicity under laser irradiation condition and enhanced anticancer activity with photothermal effect. We suggest that NGPs are a promising combination cancer therapy agent.