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      KCI등재 SCOPUS

      자궁경부편평상피세포암에서 MGMT (O6-methylguanine-DNA methyltransferase) promoter 과메칠화에 대한 연구 = Promoter hypermethylation of MGMT (O6-methylguanine-DNA methyltransferase) in cervical squamous cell carcinoma

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      https://www.riss.kr/link?id=A5065416

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      다국어 초록 (Multilingual Abstract)

      Objective: The purpose of this study is to evaluate the correlation between promoter hypermethylation of DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) and clinicopathologic characteristics in uterine cervical squamous cell carcinoma. Methods: Pyrosequencing was used to analyze the MGMT promoter methylation status of 34 uterine cervical squamous cell carcinoma. 26 patients were stage Ib and 8 patients were stage IIa. Radical hysterectomy with pelvic lymph node dissection was done in all patients. The clinicopathologic characteristics were analyzed retrospectively. The correlation between hypermethylation and clinical characteristics was assessed using Mann-Whitney U-test or Fisher`s exact test. Results: Hypermethylation was detected in 3 of 34 (8.8%) cancer tissues. We investigated the correlation between hypermethylation and clinicopathologic characteristics including age, stage, menstrual status, metastasis of lymph node, invasion of resection margin, size of tumor, lymph-vascular space invasion and invasion of parametrial tissue. Among these characteristics, only invasion of parametrial tissue was related to hypermethylation (p=0.03) and the others were not. Conclusion: Promoter hypermethylation of MGMT gene was associated with invasion of parametrial tissue only.
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      Objective: The purpose of this study is to evaluate the correlation between promoter hypermethylation of DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) and clinicopathologic characteristics in uterine cervical squamous cell carcinoma. M...

      Objective: The purpose of this study is to evaluate the correlation between promoter hypermethylation of DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) and clinicopathologic characteristics in uterine cervical squamous cell carcinoma. Methods: Pyrosequencing was used to analyze the MGMT promoter methylation status of 34 uterine cervical squamous cell carcinoma. 26 patients were stage Ib and 8 patients were stage IIa. Radical hysterectomy with pelvic lymph node dissection was done in all patients. The clinicopathologic characteristics were analyzed retrospectively. The correlation between hypermethylation and clinical characteristics was assessed using Mann-Whitney U-test or Fisher`s exact test. Results: Hypermethylation was detected in 3 of 34 (8.8%) cancer tissues. We investigated the correlation between hypermethylation and clinicopathologic characteristics including age, stage, menstrual status, metastasis of lymph node, invasion of resection margin, size of tumor, lymph-vascular space invasion and invasion of parametrial tissue. Among these characteristics, only invasion of parametrial tissue was related to hypermethylation (p=0.03) and the others were not. Conclusion: Promoter hypermethylation of MGMT gene was associated with invasion of parametrial tissue only.

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      참고문헌 (Reference)

      1 Ogino S, "Sensitive sequencing method for KRAS mutation detection by Pyrosequencing" 7 : 413-421, 2005

      2 Colella S, "Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites" 35 : 146-150, 2003

      3 Ahmadian A, "Pyrosequencing: history, biochemistry and future" 363 : 83-94, 2006

      4 Shaw RJ, "Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing" 94 : 561-568, 2006

      5 Dong SM, "Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix" 7 : 1982-1986, 2001

      6 Bosch FX, "Prevalence of human papillomavirus in cervical cancer: a worldwide perspective international biological study on cervical cancer (IBSCC) study group" 87 : 796-802, 1995

      7 Wedge SR, "Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro" 73 : 482-490, 1996

      8 Kang S, "Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer" 96 : 173-180, 2005

      9 Pollack IF, "O6- methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort" 24 : 3431-3437, 2006

      10 Schold SC Jr, "O6- alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts" 70 : 573-577, 1989

      1 Ogino S, "Sensitive sequencing method for KRAS mutation detection by Pyrosequencing" 7 : 413-421, 2005

      2 Colella S, "Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites" 35 : 146-150, 2003

      3 Ahmadian A, "Pyrosequencing: history, biochemistry and future" 363 : 83-94, 2006

      4 Shaw RJ, "Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing" 94 : 561-568, 2006

      5 Dong SM, "Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix" 7 : 1982-1986, 2001

      6 Bosch FX, "Prevalence of human papillomavirus in cervical cancer: a worldwide perspective international biological study on cervical cancer (IBSCC) study group" 87 : 796-802, 1995

      7 Wedge SR, "Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro" 73 : 482-490, 1996

      8 Kang S, "Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer" 96 : 173-180, 2005

      9 Pollack IF, "O6- methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort" 24 : 3431-3437, 2006

      10 Schold SC Jr, "O6- alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts" 70 : 573-577, 1989

      11 Wolf P, "O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer" 61 : 8113-8117, 2001

      12 Woodman CB, "Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study" 357 : 1831-1386, 2001

      13 Pegg AE, "Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents" 50 : 6119-6129, 1990

      14 Gerson SL, "MGMT: its role in cancer aetiology and cancer therapeutics" 4 : 296-307, 2004

      15 Esteller M, "Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia" 59 : 793-797, 1999

      16 Zhang YJ, "Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma" 103 : 440-444, 2003

      17 Esteller M, "Inactivation of the DNA repair gene O6- methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis" 60 : 2368-2371, 2000

      18 Middleton MR, "Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway" 4 : 37-44, 2003

      19 Korean Society of Obstetrics and Gynecology, "Gynecologic Oncology Committee. Annual report of gynecologic cancer registry program in Korea for 2004 (Jan. 1st, 2004-Dec. 31st, 2004)" 50 : 28-78, 2007

      20 Coulondre C, "Genetic studies of the lac repressor. III. Additional correlation of mutational sites with specific amino acid residues" 117 : 525-567, 1977

      21 Middleton MR, "Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model" 100 : 615-617, 2002

      22 An Q, "Detection of p16 hypermethylation in circulating plasma DNA of non-small cell lung cancer patients" 188 : 109-114, 2002

      23 Citron M, "Detection of messenger RNA from O6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues" 84 : 337-340, 1992

      24 Reesink-Peters N, "Detecting cervical cancer by quantitative promoter hypermethylation assay on cervical scrapings: a feasibility study" 2 : 289-295, 2004

      25 Dolan ME, "Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents" 87 : 5368-5372, 1990

      26 Madhusudan S, "DNA repair inhibition: a selective tumour targeting strategy" 11 : 503-511, 2005

      27 Robertson KD, "DNA methylation, methyltransferases, and cancer" 20 : 3139-3155, 2001

      28 Jemal A, "Cancer statistics" 56 : 106-130, 2006

      29 Ministry of Health and Welfare, "Annual report of the Korea central cancer registry (Published in 2003)" 2002

      30 Tost J, "Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing" 35 : 152-156, 2003

      31 Baylin SB, "Alterations in DNA methylation: a fundamental aspect of neoplasia" 72 : 141-196, 1998

      32 Virmani AK, "Aberrant methylation during cervical carcinogenesis" 7 : 584-589, 2001

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      유사연구자 (20) 활용도상위20명

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2015-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2013-01-10 학술지명변경 한글명 : Korean Journal of Obstetrics and Gynecology -> Obstetrics & Gynecology Science
      외국어명 : Korean Journal of Obstetrics and Gynecology -> Obstetrics & Gynecology Science
      KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2011-01-15 학술지명변경 한글명 : 대한산부인과학회지 -> Korean Journal of Obstetrics and Gynecology KCI등재
      2010-06-14 학술지명변경 한글명 : 대한산부인과학회잡지 -> 대한산부인과학회지 KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-05-24 학회명변경 영문명 : 미등록 -> Korean Soceity of Obstetrics and Gynecology KCI등재후보
      2005-03-22 학술지등록 한글명 : 대한산부인과학회잡지
      외국어명 : Korean Journal of Obstetrics and Gynecology
      KCI등재후보
      2005-01-01 평가 등재후보학술지 유지 (등재후보2차) KCI등재후보
      2004-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2002-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.04 0.04 0.06
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.06 0.06 0.255 0
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