SV40 전이 포유동물세포에 있어 복제기구의 크기와 자외선 감수성 = Replicon Sizes and UV - Sensitivities in SV40 - Transformed Mammalian Cells

다국어 초록 (Multilingual Abstract)

The molecular weights of pulse labeled DNA at various times after UV-irradiation declined and then recovered. The rate recovery at which their ability to synthesize control size DNA was a function of replicon size; normal human cells with small replicons recovered more rapidly than SV40 transformed cells with large replicons At low numbers of UV-lesions per replicon in normal cells, inhibition of replicon initiation was the predominant response; at higher numbers of lesions per replicons in SV40 transformed cells, blockage of chain growth was the predominant response. These results indicate that replicon size determines, in part, the response of DNA replication to UV damage.