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Chinese hamster ovary (CHO) cells exposed to ultraviolet(UV)-light and methyl methanesulfonate (MMS), analysed by alkaline sucrose gradient sedimentation, showed an interruption of DNA replication. In UV-irradiated cells, dose-dependent response appea...
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RISS 인기검색어
포유동물세포에 있어 MMS 와 자외선에 의한 복제개시 및 DNA 생장억제 = Inhibition of Replicon Initiation and Chain Elongation of DNA by Methyl Methanesulfonate and Ultraviolet Damages in Mammalian Cells
한글로보기https://www.riss.kr/link?id=A3087184
-
저자
박상대 ; 성노현 ; 이치건 ; 김영상 ; 윤정교 ( S . D . Park ; R . H . Seong ; C . G . Lee ; Y . S . Kim ; J . K . Yoon )
- 발행기관
- 학술지명
- 권호사항
-
발행연도
1983
-
작성언어
-
- 주제어
-
KDC
400
-
등재정보
SCOPUS,KCI등재,SCIE
-
자료형태
학술저널
- 발행기관 URL
-
수록면
91-99(9쪽)
- 제공처
- 소장기관
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
Chinese hamster ovary (CHO) cells exposed to ultraviolet(UV)-light and methyl methanesulfonate (MMS), analysed by alkaline sucrose gradient sedimentation, showed an interruption of DNA replication. In UV-irradiated cells, dose-dependent response appeared; at low fluences below 1.42J/m2 the inhibition of replicon initiation was caused and as the fluence increased the effect on replicon initiation was masked by the inhibitory effects on strand-elongation and joining. MMS also showed the inhibitory effects in dose dependent manner at both processes of replicon initiation and chain elongation of DNA. treatment with UV and MMS concomitantly resulted in the additive inhibition effects of DNA replication.
Chinese hamster ovary (CHO) cells exposed to ultraviolet(UV)-light and methyl methanesulfonate (MMS), analysed by alkaline sucrose gradient sedimentation, showed an interruption of DNA replication. In UV-irradiated cells, dose-dependent response appeared; at low fluences below 1.42J/m2 the inhibition of replicon initiation was caused and as the fluence increased the effect on replicon initiation was masked by the inhibitory effects on strand-elongation and joining. MMS also showed the inhibitory effects in dose dependent manner at both processes of replicon initiation and chain elongation of DNA. treatment with UV and MMS concomitantly resulted in the additive inhibition effects of DNA replication.
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