Environmentally friend process for paracetamol = Environmentally friend process for paracetamol

다국어 초록 (Multilingual Abstract)

Paracetamol, N-acetyl-para-aminophenol, is a common analgesic for headache or other minor pains. Since it was first introduced to the pharmacological market as a prescribed analgesics and antipyretic drug for children in 1950s, more than 600 different over-the-counter and prescription medicines containing paracetamol have been distributed worldwide. Despite of its prevalent use, the production of paracetamol is not much deviated from the original synthetic route where paraaminophenol is synthesized as a key intermediate. In order to overcome the chronic drawbacks of the conventional synthetic method for paracetamol including harsh reaction conditions and chemo-and regionselectivity issues, an environmentally friend and regioselective synthetic procedure has been developed from halobenzenes via the metal catalyzed amidation reaction and the followed hydroxylation reaction.