지속적 정량 주입법에 의한 뇌척수액 유출저항 측정의 실험적 고찰 = Review of Constant Infusion Method of Cerebrospinal Fluid Outflow Resistance Study

다국어 초록 (Multilingual Abstract)

The author has performed the experimental study to define the validity of the constant infusion technique used in determining the outflow resisitance(Ro) of cerebrospinal fluid(CSF). The reduced formula of the constant infusion technique in clinical setting assume that the initial resing Ro and the post-infusion equilibrium Ro are equal, which means that the Ro value in constant regardless of CSF pressure or infusion rate. Although this assumption allows such measurement to be simply and readily applicable in clinical situation, these two Ro values are practically different. So the effect of such assumption on calculated Ro data has been investigated.
Using 2 different methods Ro was measured simultaneously on each of 20 adult cats ; one method was clinically using reduced formula(RoFc) andthe other, derived from the data of CSF fromation rate which was calculated by modified Masserman's method(RoFm). Constant infusion was performed with varying state of infusion(0.01 to 0.2m/min).
Mean values of resting CSF pressure and superior sagittal sinus pressure were 8.8±2.9㎜Hg and 5.7±1.2㎜Hg respectively. Mean calculated rate of CSF formation of integrative modifiying Massereman method was 0.0183±0.003㎖/min. The maximum Ro was achieved between the rate of infusion of 0.02 and 0.03㎖/min and achieved between the range of CSF pressure of 14 and 18㎜Hg. Either in level of low CSF pressure or in rate of low infusion, RoFc showed remarkably higher values than RoFm. But this difference did not distinguished in the higher range of CSF pressure of infusion rate. The minmum and maxmum value of RoFc differed the more and RoFm, the less.
These findings suggest that in order to obtain more accurate Ro data with constant infusion technique, it must be corrected in low range of CSF pressure or the rate of infusion should be increased several times as that of CSF formation at the risk of possibility of induction of a pressure wave.