정상 대조군과 알레르기 질환군에서의 혈청 IgE 측정치에 관한 연구 = 정상 대조군과 알레르기 질환군에서의 혈청 IgE 측정치에 관한 연구

다국어 초록 (Multilingual Abstract)

Estimate of serum IgE levels has become apart of the diagnostic assessment of the patient with est ablished or suspected allergic diseases. The interpretation of such estim ates must, however, depend on the availability of stand ard of norm alcy for given population and serum IgE levels, because of differences of serum IgE levels with age, sexrace, community, smoking and secretor status of ABH substances, High levels ef serum IgE are associated with certain alle rgic conditions such as bronchial asthma, allergic rhi nitis, atopic dermatitis and chronic urticaria and also some parasite infestatio ns, interstitial nephritis, syphilis, drugal lergy, Wiskott Aldrich syndrome, viral infection, chronic infection, infectious mononucleosis, cryptogenic eosinophilia and some malig nancies. Serum IgE was determined by radioimmuno assay technique (PRIST) in 75 healthy Koreans and 308 patients with allergic disease (79 patients with bronchial asthma, 105 patients with allergic rhinitis, 50 patients with chronic urticaria and 74 patients with chronic cough, The results were as following. 1) Mean serum IgE value of 75 healthy Koreans was 74+ -63IU/ml. The difference of the mean serum IgE values among each age groups was not st atistically sig nificant. There was also no significant difference between male and female. 2) Serum IgE values were elevated more than 1 6 QIU /ml in 81. 0 % of bronchial asthma, 75. 2% of allergic rhinitis, 7 0. 0% of chronic urticaria and 74. 3% of chronic cough. 3) There was no significant difference ef serum IgE values between early and later age group of onset of bronchial asthma, but allergic rhinitis showed difference between age groups of onset of disease. 4) No signi 5cant difference of serum IgE values between positive and negative allergic skin test group with bronchial asthmanor allergic rhinitis was found. 5) There was no significant dif ference of serum IgE values between positive and negative dermoraphism group with chronic urticaria. 6) No significant correlation between total peripheral eosinophil counts and serum IgE values was found.