P224 Association of lichen planus and hepatitis C virus infection in the Busan, Korea = P224 Association of lichen planus and hepatitis C virus infection in the Busan, Korea

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Background: Lichen planus (LP) is a chronic inflammatory mucocutaneous disease and its association with hepatitis C virus (HCV) infection has been suggested in many studies. But reported prevalence of HCV infection in patients with LP tends to appear wide international variable between 0 and 70%. Objectives: The purpose of this study is to assess the prevalence of HCV infection in patients with LP in Busan, Korea and association between the two diseases. Methods: We reviewed medical records of 65 patients of LP, who lived in Busan, at our department of dermatology from May 1992 to April 2016. We investigated medical history, clinical, and laboratory findings including anti-HCV antibody and HCV RNA via reverse transcription-polymerase chain reaction (RT-PCR) for evaluation of HCV infection and liver function test (LFT). Results: Six patients (9.2%) were positive for anti-HCV antibody and all of them were confirmed with RT-PCR. Percentage of HCV infection among 65 patients of LP in this study was higher than that among adult in Busan (1.1%). Two patients (3.1%) were positive for hepatitis B surface antigen. Abnormal values in LFT were observed in 16 patients (24.6%) and liver diseases were observed in 7 patients (10.8%). Other associated diseases were hypertension, diabetes mellitus, and cardiac disease. Conclusion: LP is associated with HCV infection and it would be necessary to investigate HCV infection and liver disease in the LP patients.