자연과학편 : 규칙적인 운동이 2형 당뇨환자의 에너지 기질 이용에 미치는 영향 = The effects of regular exercise on substrate utilization in Type 2 diabetic mellitus

다국어 초록 (Multilingual Abstract)

Although substrate metabolism during exercise has been extensively investigated in healthy physically trained individual, less is known about patterns of substrate utilization during exercise in type II diabetes mellitus. The objectives of this study were to investigate the effects of regular exercise on substrate utilization during walking exercise in patients with type II diabetes mellitus. 50 type 2 diabetic subjects who have performed physical exercise 3-5 times per week (EG) and 50 type 2 diabetic subjects who have not (NEG) were recruited. Each patient was at rest in a sitting position and then performed walking exercise of 26 minutes' duration. Blood glucose and lactate were measured before the exercise and immediately after the exercise. substrate oxidation was assessed by indirect calorimetry during the period of rest, exercise and recovery respectively. Blood glucose was significantly lower in the EG group(p<.05). Blood lactate was same in the EG and NEG group. The mean values of VO2, RER and Glucose oxidation during exercise were significantly higher in the EG group(p<.001, .05 and p<.001, respectively ). Lipid oxidation was same in the EG and NEG group.

These data suggest that type 2 diabetes with regular exercise decrease in blood glucose level and shifts towards a predominance of carbohydrate oxidation during walking exercise higher than in NEG group.

참고문헌 (Reference)

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