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4-Hydroxybenzyl alcohol (4-HB alcohol) is one of the major active components of Gastrodia elata Blume, with beneficial effects on neurological disorders such as headache, convulsive behavior, and dizziness. Here, we developed a metabolically engineere...
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RISS 인기검색어
대사공학에 의해 개발된 코리네박테리움 글루타미컴에 의한 4-히드록시벤질 알코올 생산 = Production of 4-Hydroxybenzyl Alcohol Using Metabolically Engineered Corynebacterium glutamicum
한글로보기https://www.riss.kr/link?id=A107178114
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2020
-
작성언어
-
- 주제어
-
KDC
400
-
등재정보
SCOPUS,KCI등재
-
자료형태
학술저널
- 발행기관 URL
-
수록면
506-514(9쪽)
-
KCI 피인용횟수
0
- DOI식별코드
- 제공처
- 소장기관
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
4-Hydroxybenzyl alcohol (4-HB alcohol) is one of the major active components of Gastrodia elata Blume, with beneficial effects on neurological disorders such as headache, convulsive behavior, and dizziness. Here, we developed a metabolically engineered Corynebacterium glutamicum strain able to produce 4-HB alcohol from 4-hydroxybenzoate (4-HBA). First, the strain APS963 was obtained from the APS809 strain via the insertion of aroK from Methanocaldococcus jannaschii into the NCgl2922-deleted locus. As carboxylic acid reductase from Nocardia iowensis catalyzes the reduction of 4HBA to 4-hydroxybenzaldehyde (4-HB aldehyde), we then introduced a codon-optimized car gene into the genome of APS963, generating the GAS177 strain. Then, we deleted creG coding for a putative short-chain dehydrogenase and inserted ubiCpr encoding a product-resistant chorismate-pyruvate lyase into the pcaHG-deleted locus. The resulting engineered GAS355 strain accumulated 2.3 g/l 4-HB alcohol with 0.32 g/l 4-HBA and 0.3 g/l 4-HB aldehyde as byproducts from 8% glucose after 48 h of culture.
4-Hydroxybenzyl alcohol (4-HB alcohol) is one of the major active components of Gastrodia elata Blume, with beneficial effects on neurological disorders such as headache, convulsive behavior, and dizziness. Here, we developed a metabolically engineered Corynebacterium glutamicum strain able to produce 4-HB alcohol from 4-hydroxybenzoate (4-HBA). First, the strain APS963 was obtained from the APS809 strain via the insertion of aroK from Methanocaldococcus jannaschii into the NCgl2922-deleted locus. As carboxylic acid reductase from Nocardia iowensis catalyzes the reduction of 4HBA to 4-hydroxybenzaldehyde (4-HB aldehyde), we then introduced a codon-optimized car gene into the genome of APS963, generating the GAS177 strain. Then, we deleted creG coding for a putative short-chain dehydrogenase and inserted ubiCpr encoding a product-resistant chorismate-pyruvate lyase into the pcaHG-deleted locus. The resulting engineered GAS355 strain accumulated 2.3 g/l 4-HB alcohol with 0.32 g/l 4-HBA and 0.3 g/l 4-HB aldehyde as byproducts from 8% glucose after 48 h of culture.
참고문헌 (Reference)
1 Kim HJ, "Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia" 1181 : 130-141, 2007
2 Podstolski A, "Unusual 4-hydroxybenzaldehyde synthase activity from tissue cultures of the vanilla orchid Vanilla planifolia" 61 : 611-620, 2002
3 Rodriguez GM, "Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli" 25 : 227-237, 2014
4 Schäfer A, "Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19 : selection of defined deletions in the chromosome of Corynebacterium glutamicum" 145 : 69-73, 1994
5 Purwanto HS, "Rational engineering of the shikimate and related pathways in Corynebacterium glutamicum for 4-hydroxybenzoate production" 282 : 92-100, 2018
6 Lee JH, "Production of amino acids-Genetic and metabolic engineering approaches" 245 : 1575-1587, 2017
7 김유미, "Production of Indole-3-acetate in Corynebacterium glutamicum by Heterologous Expression of the Indole-3-pyruvate Pathway Genes" 한국미생물·생명공학회 47 (47): 242-249, 2019
8 He A, "Nocardia sp. carboxylic acid reductase: cloning, expression, and characterization of a new aldehyde oxidoreductase family" 70 : 1874-1881, 2004
9 김진연, "N-아세틸글루코사민 생산을 위한 코리네박테리움 글루타미컴의 대사공학" 한국미생물·생명공학회 47 (47): 78-86, 2019
10 Eggeling L, "Handbook of Corynebacterium glutamicum" CRC Press 540-544, 2005
1 Kim HJ, "Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia" 1181 : 130-141, 2007
2 Podstolski A, "Unusual 4-hydroxybenzaldehyde synthase activity from tissue cultures of the vanilla orchid Vanilla planifolia" 61 : 611-620, 2002
3 Rodriguez GM, "Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli" 25 : 227-237, 2014
4 Schäfer A, "Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19 : selection of defined deletions in the chromosome of Corynebacterium glutamicum" 145 : 69-73, 1994
5 Purwanto HS, "Rational engineering of the shikimate and related pathways in Corynebacterium glutamicum for 4-hydroxybenzoate production" 282 : 92-100, 2018
6 Lee JH, "Production of amino acids-Genetic and metabolic engineering approaches" 245 : 1575-1587, 2017
7 김유미, "Production of Indole-3-acetate in Corynebacterium glutamicum by Heterologous Expression of the Indole-3-pyruvate Pathway Genes" 한국미생물·생명공학회 47 (47): 242-249, 2019
8 He A, "Nocardia sp. carboxylic acid reductase: cloning, expression, and characterization of a new aldehyde oxidoreductase family" 70 : 1874-1881, 2004
9 김진연, "N-아세틸글루코사민 생산을 위한 코리네박테리움 글루타미컴의 대사공학" 한국미생물·생명공학회 47 (47): 78-86, 2019
10 Eggeling L, "Handbook of Corynebacterium glutamicum" CRC Press 540-544, 2005
11 Li T, "Genetic characterization of 4-cresol catabolism in Corynebacterium glutamicum" 192 : 355-365, 2014
12 Song C, "Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord" 8 : 1383-1389, 2013
13 Park S, "Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats : vanillin and 4-hydroxybenzaldehyde are the bioactive candidates" 50 : 107-118, 2010
14 Gibson DG, "Enzymatic assembly of DNA molecules up to several hundred kilobases" 6 : 343-345, 2009
15 Han SS, "Engineering of the conformational dynamics of an enzyme for relieving the product inhibition" 6 : 8440-8445, 2016
16 이진호, "Development and Characterization of Expression Vectors for Corynebacterium glutamicum" 한국미생물·생명공학회 24 (24): 70-79, 2014
17 Bai Y, "De novo biosynthesis of gastrodin in Escherichia coli" 35 : 138-147, 2016
18 Wendisch VF, "Corynebacterium glutamicum. Microbiology Monographs, Vol 23" Springer 287-322, 2020
19 Gahloth D, "Carboxylic acid reductase : Structure and mechanism" 307 : 107-113, 2020
20 Lee JH, "Biotechnological production of aromatic compounds of the extended shikimate pathway from renewable biomass" 257 : 211-221, 2017
21 Luo L, "Anti-oxidative effects of 4-hydroxybenzyl alcohol in astrocytes confer protective effects in autocrine and paracrine manners" 12 : e0177322-, 2017
22 Liu Y, "A review on central nervous system effects of gastrodin" 9 : 24-, 2018
23 Yu SS, "4-Hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action" 36 : 339-346, 2011
24 Kang CW, "4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes" 7 : 14192-, 2017
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분석정보
인용정보 인용지수 설명보기
학술지 이력
| 연월일 | 이력구분 | 이력상세 | 등재구분 |
|---|---|---|---|
| 2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
| 2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
| 2015-09-23 | 학술지명변경 | 외국어명 : Korean Journal of Microbiology and Biotechnology -> Microbiology and Biotechnology Letters | |
| 2010-01-01 | 평가 | 등재 1차 FAIL (등재유지) | |
| 2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2004-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2001-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
| 1998-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |  |
학술지 인용정보
| 기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
|---|---|---|---|
| 2016 | 0.6 | 0.6 | 0.65 |
| KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
| 0.53 | 0.55 | 0.977 | 0.18 |
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