구속(拘束)스트레스로 유발된 생쥐 시상하부내(視床下部內) Monoamine의 변화에 대한 시호소간산(柴胡疎肝散)과 시호억간탕(柴胡抑肝湯)의 효능 = Effect of Chaihushugansan and Chaihuyigantang on the change of Monoamine Contents in the Hypothalamus of Mice induced by the Immobilization Stress

다국어 초록 (Multilingual Abstract)

This study aimed to investigate the effects of Chaihushugansan and Chaihuyigantang on the change of monoamine-contents in the hypothalamus of mice induced by the immobilization stress. Each formula(1.0g/kg) was injected intragastrically to mice 1 hour prior to the immobilzation stress(15 minutes) before measuring the change of monoamine-contents level in mice hypothalamus. The results were as follows: 1. DA content at control group showed significant change. CHSGS group and CHYGT group showed significant decrease.(P<0.05) 2. NE content of the control group was increased than normal group. NE content of the CHYGT group was shown a significant decrease than control group.(P<0.05) 3. DOPAC contents didn't show significant changes at any groups. 4. 5-HT contents didn't show significant changes at any groups. 5. 5-HIAA contents at CHSGS group and CHYGT group showed signifiant changes.(P<0.05, 0.01) These data revealed that chaihushugansan and chaihuyigantang might have the anti-stress effect through the control of DA and NE contents in the hypothalamus.