고려 홍삼이 암독소 호르몬-L의 체지방 분해작용에 미치는 영향 = Effect of Korean Red Ginseng on Lipolytic Action of Toxohormone-L from Cancerous Ascites Fluid

다국어 초록 (Multilingual Abstract)

This study was devised to observe the inhibitory effects of 3 kinds of petroleum ether extracts (percolation by petroleum ether), methanol treatment residue material (percolation by methanol) and ethanol treatment precipitate (crude acidic polysaccharide) from Korean red ginseng, Chinese red ginseng and American white ginseng on a lipolytic action of Toxohormone - L which has been known as lipolytic and anorexigenic factors.
Toxohormone - L was obtained by partial purification of the ascites fluid from mice which has been inoculated with sarcoma -180. The yields of crude acidic polysaccharide from Korea red ginseng, Chinese red ginseng and American white ginseng were 63.5, 61.3 and 60.4% respectively, indicating that the Korean red ginseng was the highest.
In vitro, at the concentration of 2㎍/㎖, the total inhibitory activity of lipolysis by the petroleum ether extract of Korean red ginseng, Chinese red ginseng and American white ginseng per gram of ginseng material were 18, 12 and 13 unit respectively, indicating that the Korean red ginseng was the most effective in the inhibition of the lipolysis. And then at the concentration of 500㎍/㎖, the inhibition rate of lipolysis by the methanol treatment residue material of Korean red ginseng, Chinese red ginseng and American white ginseng were 36.8, 32.6 and 29.5% respectively, and that of lipolysis by the crude acidic polysaccharide of each ginseng were 38.8, 34.7 and 37.8% respectively, and the total inhibitory activity per gram of ginseng material were 4.9×10³, 4.3×10³ and 4.6×10³unit respectively, also indicating that the Korean red ginseng was the most effective in the inhibition of the lipolysis.