한국인 정상안에서 우세안과 비우세안 사이의 빛간섭단층혈관조영 측정치의 대칭성 = Symmetry of Optical Coherence Tomography Angiography Parameters between Dominant and Non-dominant Eyes in Healthy Koreans

다국어 초록 (Multilingual Abstract)

Purpose: To assess the symmetry of microvascular parameters measured via optical coherence tomography angiography (OCTA) between the dominant and non-dominant eyes of normal Korean subjects.
Methods: We retrospectively analyzed data on 120 eyes of 60 healthy Koreans. The ‘hole-in-the-card’ technique was used to determine ocular dominance. Central macular, peripapillary retinal nerve fiber layer thickness, and macular ganglion cell-inner plexiform layer thickness, were measured via spectral domain OCT. Vessel and perfusion density and the area of the foveal avascular zone (FAZ) were measured via OCTA. We used the paired t-test to compare all between-eye parameters. We calculated areas under receiver operating characteristic curves to determine diagnostic utility.
Results: The average participant age was 27.4 ± 2.01 years. Forty-one subjects (68.3%) were right eye-dominant and 19 (31.7%) left eye-dominant. None of the central macular, macular GC-IPL, or peripapillary RNFL thickness differed between the eyes; neither did any OCTA-assessed microvascular parameter (vessel or perfusion density or the FAZ area).
Conclusions: No OCT or OCTA parameter differed between dominant and non-dominant eyes. No parameter identified ocular dominance.

국문 초록 (Abstract)

목적: 한국인 정상안에서 우세안과 비우세안 사이의 빛간섭단층촬영(optical coherence tomography, OCT), 빛간섭단층혈관조영(OCT angiography, OCTA) 측정값의 차이를 분석하고자 하였다.
대상과 방법: 정상 성인 60명의 120안을 대상으로 후향적 방식으로 연구하였다. Hole-in-the-card test를 시행하여 우세안을 결정하였다. 빛간섭단층촬영을 시행하여 중심 황반부, 황반부 신경절세포-내망상층, 유두주위 망막신경섬유층의 두께를 분석하였다. 빛간섭단층혈관조영술을 시행하여 황반부의 혈관 밀도, 관류 밀도, 망막중심오목무혈관부위의 둘레와 면적을 분석하였다. 우세안과 비우세안 사이의 OCT, OCTA 측정값들의 차이를 paired t-test를 이용하여 비교 분석하였다. 각각의 OCT, OCTA 지표들의 area under the receiver operating characteristic curve를 구하여 진단 가치를 판단하였다.
결과: 대상군의 평균 나이는 27.4 ± 2.01세, 우세안은 우안 41안(68.3%), 좌안이 19안(31.7%)이었다. OCT 검사에서 우세안과 비우세안 간의 평균 중심황반두께, 황반부 신경절세포층–내망상층두께, 유두주위 망막신경섬유층두께에 차이가 없었다. OCTA 검사에서 두 군 간 표층모세혈관망의 혈관 밀도, 관류 밀도, 망막중심오목무혈관부위 넓이에는 유의한 차이가 없었다.
결론: 우세안과 비우세안 사이의 OCT, OCTA 측정값에는 유의한 차이가 없었다. 또한 OCT, OCTA의 측정치로는 우세안과 비우세안을 구별할 수 없었다.

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